抗感染纳米羟基磷灰石局部药物缓释微球的研制及体外释药实验

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1、抗感染纳米羟基磷灰石局部药物缓释微球的研制及体外释药实验作者：王永峰1；靳安民1；魏坤2；王旭东2；汤善华1；闵少雄1　　(1南方医科大学珠江医院骨科中心，广东广州510282；2华南理工大学材料学院，广东  广州  510641)摘要：目的  研制抗感染纳米羟基磷灰石(nano-HA)药物缓释微球，为骨髓炎的治疗提供一新型的局部药物缓释系统(DDS)。方法采用nano-HA为载药核心载体，外包裹生物相容性好且可降解的聚羟基丁酸酯-羟基戊酸酯共聚物/聚乙二醇(PHBV/PEG)，承载硫酸庆大霉素(GM)制成nano-HA-PHBV/PEG-GM缓释微球

2、，研究其结构及体外释药特性。结果  微球具有明显缓释作用，90mgDDS体外释放实验显示第1天释放量为165.2μg/mL，其后下降并以较低水平稳定释放，维持有效释药时间在28d以上。结论  抗感染nano-HA药物缓释微球具有良好的体外缓释作用，有广泛的应用前景。关键词：纳米羟基磷灰石；聚羟基丁酸酯-羟基戊酸酯共聚物；聚乙二醇；硫酸庆大霉素；局部药物释放系统中图分类号：R912；TQ467  文献标识码：A  文章编号：1673-4254(2006)06-0754-03Developmentofananti-infectionnano-hydroxy

3、patitedrugdeliverymicrosphereanditsdrug-releaseinvitroWANGYong-feng1；JINAn-min1；WEIKun2；WANGXu-dong2；TANGShan-hua1；MINShao-xiong11DepartmentofOthopedics,ZhujiangHospital,SouthernMedicalUniversity,Guangzhou510282,China;2InstituteofMaterialScienceandEngineering,SouthChinaUniversit

4、yofTechnology,Guangzhou510641,ChinaAbstract:ObjectiveTodevelopananti-infectionnano-hydroxypatite(nano-HA)microsphereforlocaldrugdeliveryfortreatingosteomyelitis.MethodsThenano-HAwasusedasthecorecarriertoloadgentamicin(GM)andcoatedwithpoly(-hydroxybutyrate-co-hydroxyvalerate)/pol

5、yethyleneglycol(PHBV/PEG),whichwasdegradableandbiocompatible,topreparenano-HA-PHBV/PEG-GMmicrosphere.Thesurfacestructureandinvitrodrug-releaseofthemicrospherewerestudied.ResultsThemicrospherehadgooddrugdeliverycapability.Thesamplesweighing90mgeachweresoakedinPBSandgentamicinrele

6、asewithinthefirstdaywas165.2μg/ml,whichmaintainedalowreleaserateinthefollowingdays.After28days,gentamicinreleasedeclinedto8.5μg/ml,whichwashigherthantheminimalinhibitoryconcentrationofgentamicin(2μg/ml).ConclusionThelocaldrugdeliverysystemhasgooddrug-releaseperformanceinvitroand

7、maypossesspotentialvalueinclinicalmanagementofosteomyelitis.Keywords:nano-hydroxyapatite;poly(-hydroxybutyrate-co-hydroxyvalerate);polyethyleneglycol;gentamicinsulfate;localdrugdeliverysystem收稿日期：2005-11-28基金项目：国家自然科学基金(50272021)；广东省重点攻关项目(A302020205)SupportedbyNationalNaturalSc

8、ienceFoundationofChina(50272021)andtheKeySci-te