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时间:2018-04-15
《两种手术方式治疗真菌性角膜炎的临床观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·36·中国真菌学杂志2014年2月第9卷第1期ChinJMycol,February2014,Vol9,No.1·真菌病治疗·两种手术方式治疗真菌性角膜炎的临床观察陈金鹏汪荣徐辉勇张鹏章剑(武汉大学医学院附属鄂州市中心医院,鄂州436000)【摘要】目的观察深板层角膜移植术(deeplamellarkeratoplasty,DLKP)和穿透性角膜移植术(penetratingkeratoplasty,PKP)治疗真菌性角膜炎的临床疗效。方法回顾44例(44眼)临床确诊为真菌性角膜炎的患者,根据共焦激光显微
2、镜检查是否累及角膜内皮分别行DLKP28例(28眼)或PKP16例(16眼)。术后随访6~24个月,观察术后真菌复发情况以及拆线后两周视力和角膜地形图散光。结果术后角膜病理切片检查均检出真菌。术后DLKP组有1例、PKP组有3例出现排斥反应,经抗排斥治疗后均好转。拆线后两周最佳矫正视力DLKP组为0.59±0.04,PKP组为0.41±0.05,两组间相比较差异具有统计学意义(t=2.577,P=0.01);角膜地形图散光DLKP组为(2.0±0.17)D;PKP组为(2.9±0.30)D,两组间相比较差异
3、具有统计学意义(t=0.088,P=0.016)。结论激光共焦显微镜检查对于手术方式的选择提供了良好的客观依据。两种手术方式治疗真菌性角膜炎均有良好的疗效,DLKP术后视觉疗效优于PKP。【关键词】真菌性角膜炎;深板层角膜移植;穿透性角膜移植【中图分类号】R772.22【文献标识码】A【文章编号】1673-3827(2014)09-0036-03ClinicalobservationoftwodifferentoperationsintreatmentoffungalkeratitisCHENJin-pen
4、g,WANGRong,XUHui-yong,ZHANGPeng,ZHANGJian(EzhouCentralHospital,MedicalCollegeofWuhanUniversity,Ezhou436000,China)【Abstract】ObjectiveToevaluatetheefficacyandsafetyofdeeplamellarkeratoplasty(DLKP)andpenetratingkeratoplasty(PKP)inthetreatmentoffungalkeratitis
5、.MethodsForty-fourpatients(44eyes)werediagnosedasfungalkeratitisandnoobvi-ouseffectwithdrugtreatment.DLKP(28cases,28eyes)orPKP(16cases,16eyes)wasperformedaccordingtowhetherin-volvedcornealendotheliumbyconfocallasermicroscopy.Patientswerefollowedupfor6to24m
6、onthstoobserverecurrencepostop-eration,visualacuityandcornealtopographyastigmatismtwoweeksaftersutureremoval.ResultsCornealhistologiacalexamina-tionsofallcasesweredetectedoffungus.OneeyebyDLKPandthreeeyesbyPKPappearedgraftedemaandimprovedafteranti-re-jecti
7、ontherapy.Thebestcorrectedvisualacuity(BCVA)ofDLKPgroupwas0.59±0.04,andBCVAofPKPgroupwas0.41±0.05,therewassignificantstatisticallydifference(t=2.577,P=0.01).ThecornealtopographicastigmatismofDLKPgroupwas(2.0±0.17)D,andthatofPKPgroupwas(2.9±0.30)D,therewass
8、tatisticallydifference(t=0.088,P=0.016).Conclu-sionsLaserconfocalmicroscopyishelpfulinthediagnosisoffungalkeratitisandinjudgingthedepthofthefilamentinfiltration,providingafavourableobjectiveevidenceforchoiceo
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