non contact fluorescence optical tomography with scanning patterned illumination外语英文电子书

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1、Non-contactfluorescenceopticaltomographywithscanningpatternedilluminationAmitJoshi,1WolfgangBangerth,2andEvaM.Sevick-Muraca1amitj@bcm.tmc.edu,bangerth@math.tamu.edu,evas@bcm.edu1DivisionofMolecularImaging,DepartmentofRadiology,BaylorCollegeofMedicine,Houston,TX7

2、70302DepartmentofMathematics,TexasA&MUniversity,CollegeStation,TX77840Abstract:Thisarticledescribesanovelnon-contactfluorescenceopticaltomographyschemewhichutilizesmultipleareailluminationpatterns,toreducetheill-posednessoftheinverseprobleminvolvedinrecoveringin

3、teriorfluorescenceyielddistributionsinbiologicaltissuefromboundaryfluorescencemeasurements.Theimagereconstructionisposedasanoptimizationproblemwhichseeksatissueopticalpropertydistributionminimizing,forallilluminationpatternssimultaneously,aregularizeddifferencebe

4、tweentheobservedboundarymeasurementsoflightdistribu-tion,andtheboundarymeasurementspredictedfromaphysicalmodel.MultipleexcitationsourceilluminationpatternsaredescribedbylineandGaussiansourcesscanningthesimulatedtissuephantomsurfaceandbyemployingdiffractiveoptic

5、s-generatedpatterns.Multiplemeasurementdatasetsgeneratedbyscanningexcitationsourcesareprocessedsimultaneouslytogeneratetheinteriorfluorescencedistributionintissuebyimplementingthefluorescencetomographyalgorithminaparallelframeworksuitableformultiprocessorcomputer

6、s.Imagereconstructionsforsingleandmultiplefluorescenttargets(5mmdiameter)embeddedina512mlsimulatedtissuephantomaredemonstrated,withdepthsofthefluorescenttargetsfromtheilluminationplanebetween1cmto2cm.Weshowbothqualitativeandquantitativeimprovementsofouralgorithmo

7、verreconstructionsfromonlyasinglemeasurement.©2006OpticalSocietyofAmericaOCIScodes:(170.3010)ImageReconstructionTechniques;(170.5280)PhotonMigration;(170.3880)MedicalandBiologicalImaging.Referencesandlinks1.M.A.O'Leary,D.A.Boas,B.Chance,andA.G.Yodh.Reradiationa

8、ndimagingofdiffusephotondensitywavesusingfluorescentinhomogeneities.J.Luminescence,60:281–286,1994.2.M.A.O'Leary,D.A.Boas,B.Chance,andA.G.Yodh.Fluorescencelifetimeimagingintu