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1、HomeSearchCollectionsJournalsAboutContactusMyIOPscienceParetonavigation—algorithmicfoundationofinteractivemulti-criteriaIMRTplanningThisarticlehasbeendownloadedfromIOPscience.Pleasescrolldowntoseethefulltextarticle.2008Phys.Med.Biol.53985(http://iopscience.iop.org/0031-91
2、55/53/4/011)Viewthetableofcontentsforthisissue,orgotothejournalhomepageformoreDownloaddetails:IPAddress:202.201.0.66Thearticlewasdownloadedon18/11/2012at07:39Pleasenotethattermsandconditionsapply.IOPPUBLISHINGPHYSICSINMEDICINEANDBIOLOGYPhys.Med.Biol.53(2008)985998doi:10.1
3、088/0031-9155/53/4/011Paretonavigation—algorithmicfoundationofinteractivemulti-criteriaIMRTplanningMMonz1,KHKufer¨1,TRBortfeld2andCThieke31DepartmentofOptimization,FraunhoferInstituteforIndustrialMathematics(ITWM),FraunhoferPlatz1,67663Kaiserslautern,Germany2DepartmentofR
4、adiationOncology,MassachusettsGeneralHospitalandHarvardMedicalSchool,30FruitStreet,Boston,MA02114,USA3DepartmentofRadiationOncology,GermanCancerResearchCenterandUniversityClinicHeidelberg,ImNeuenheimerFeld280,69120Heidelberg,GermanyE-mail:monz@itwm.fhg.deReceived26Septemb
5、er2007,infinalform8January2008Published24January2008Onlineatstacks.iop.org/PMB/53/985AbstractInherently,IMRTtreatmentplanninginvolvescompromisingbetweendifferentplanninggoals.Multi-criteriaIMRTplanningdirectlyaddressesthiscompromisingandthusmakesitmoresystematic.Usually,se
6、veralplansarecomputedfromwhichtheplannerselectsthemostpromisingfollowingacertainprocedure.ApplyingParetonavigationforthisselectionstepsimultaneouslyincreasesthevarietyofplanningoptionsandeasestheidentificationofthemostpromisingplan.Paretonavigationisaninteractivemulti-crit
7、eriaoptimizationmethodthatconsistsofthetwonavigationmechanismsselectionandrestriction.Theformerallowstheformulationofwisheswhereasthelatterallowstheexclusionofunwantedplans.Theyarerealizedasoptimizationproblemsontheso-calledplanbundleasetconstructedfrompre-computedplans.T
8、heycanbeapproximatelyreformulatedsothattheirsolutiontimeisasmallfractionofasecond.Thus,theuserca
