fetuin-a is associated with calcified coronary artery disease

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1、Diagnosticmethods281Fetuin-AisassociatedwithcalcifiedcoronaryarterydiseaseacaabKatsuhitoMori,YujiIkari,ShuichiJono,MasanoriEmoto,AtsushiShioi,aaaacHidenoriKoyama,TetsuoShoji,EijiIshimura,MasaakiInaba,KazuhiroHaraaandYoshikiNishizawaObjectiveFetuin-Aisacirculati

2、ngglycoproteinthatisrespectively;P=0.010).Multivariatelogisticregressioninvolvedinvariousstagesofatherosclerosis.Despitetheanalysisrevealedthatfetuin-Alevelsinverselyfactthatemergingevidencesuggestsfetuin-Aactsascorrelatedwiththepresenceofcoronaryarteryacalcifi

3、cationinhibitorthatprotectsagainstadvancedcalcification(oddsratio:0.54;95%confidenceinterval:calcifiedatherosclerosisindialyzedpatients,theroleof0.31–0.92;P=0.025).fetuin-Aincardiovasculardiseaseisstillcontroversial.ConclusionSerumfetuin-Alevelsinverselycorrela

4、tedAsdiabetesanduremiamaketheroleoffetuin-Ainwithadvancedcalcifiedcoronaryarterydisease.Coroncardiovasculardiseaseuncertain,weinvestigatedtheArteryDis21:281–285c2010WoltersKluwerHealth

5、associationbetweenfetuin-AandcalcifiedcoronaryLippincottWilliams&Wilkins.art

6、erydiseaseinparticipantswithoutdiabetesandrenaldysfunction.CoronaryArteryDisease2010,21:281–285MethodsSerumfetuin-AlevelsweremeasuredinKeywords:Alpha-2-HeremansSchmidglycoprotein,atherosclerosis,coronaryarterycalcification,coronaryarterydisease,fetuin-A92partic

7、ipantswhounderwentcoronaryangiography.ThenumberofdiseasedvesselsandthepresenceofaDepartmentsofMetabolism,Endocrinology,andMolecularMedicine,calcificationwereevaluated.bCardiovascularMedicine,OsakaCityUniversityGraduateSchoolofcMedicine,OsakaandDivisionofCardiol

8、ogy,MitsuiMemorialHospital,ResultsFetuin-AlevelssignificantlydecreasedinpatientsTokyo,Japanwithadvancedthree-vesseldiseasecomparedwithCorrespondencetoDrKatsuhitoMori,MD,PhD,DepartmentofMetabolism,thosewithoutstenosis(245.5±50.9,289.0±71.8lg/ml,Endocrinology,and

9、MolecularMedicine,OsakaCityUniversityGraduaterespectively;P<0.05).Likewise,fetuin-AlevelswereSchoolofMedicine,1-4-3,Asahi-machi,Abeno-ku,Osaka545-8585,JapanTel:+81666453806;