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1、EpidemiologyandPreventionSouthernDietaryPatternIsAssociatedWithHazardofAcuteCoronaryHeartDiseaseintheReasonsforGeographicandRacialDifferencesinStroke(REGARDS)StudyJamesM.Shikany,DrPH;MonikaM.Safford,MD;P.K.Newby,ScD,MPH,MS;RaeganW.Durant,MD;ToddM.Brown,MD;SuzanneE.Judd,PhDBackgroun
2、d—Theassociationofoveralldiet,ascharacterizedbydietarypatterns,withriskofincidentacutecoronaryheartdisease(CHD)hasnotbeenstudiedextensivelyinsamplesincludingsociodemographicandregionaldiversity.MethodsandResults—Weuseddatafrom17418participantsinReasonsforGeographicandRacialDifferen
3、cesinStroke(REGARDS),anational,population-based,longitudinalstudyofwhiteandblackadultsaged≥45years,enrolledfrom2003to2007.WederiveddietarypatternswithfactoranalysisandusedCoxproportionalhazardsregressiontoexaminehazardofincidentacuteCHDevents–nonfatalmyocardialinfarctionandacuteCHD
4、death–associatedwithquartilesofconsumptionofeachpattern,adjustedforvariouslevelsofcovariates.Fiveprimarydietarypatternsemerged:Convenience,Plant-based,Sweets,Southern,andAlcoholandSalad.Atotalof536acuteCHDeventsoccurredoveramedian(interquartilerange)5.8(2.1)yearsoffollow-up.Afterad
5、justmentforsociodemographics,lifestylefactors,andenergyintake,highestconsumersoftheSouthernpattern(characterizedbyaddedfats,friedfood,eggs,organandprocessedmeats,andsugar-sweetenedbeverages)experienceda56%higherhazardofacuteCHD(comparingquartile4withquartile1:hazardratio,1.56;95%co
6、nfidenceinterval,1.17–2.08;Pfortrendacrossquartiles=0.003).Addinganthropometricandmedicalhistoryvariablestothemodelattenuatedtheassociationsomewhat(hazardratio,1.37;95%confidenceinterval,1.01–1.85;P=0.036).Conclusions—AdietarypatterncharacteristicofthesouthernUnitedStateswasassocia
7、tedwithgreaterhazardofCHDDownloadedfromhttp://ahajournals.orgbyonAugust6,2018inthissampleofwhiteandblackadultsindiverseregionsoftheUnitedStates.(Circulation.2015;132:804-814.DOI:10.1161/CIRCULATIONAHA.114.014421.)KeyWords:coronarydisease◼diet◼epidemiology◼follow-upstudies◼nutrition
8、assessmentlthoughcoronaryh