最新乳房病病理学 PPT课件-药学医学精品资料.ppt

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1、最新乳房病病理学PPT课件-药学医学精品资料LectureObjectivesAttheendofthelecturethestudentshouldbeableto:1.Discusstheetiology/pathologicfeaturesofdifferentformsofbenignnon-neoplasticandneoplasticbreastdisease.2.Listthebenignbreastdiseasesthatincreaseapatient’sriskofdevelopingbreastcancerandclassifythese

2、conditionsbythedegreeofrisk.2医学课件LectureObjectivesAttheendofthelecturethestudentshouldbeableto:3.Outlineotherriskfactorspredisposingtobreastcancer&incidence/prevalenceofbreastcancer.4.Classifybreastcancerintohistologicsubtypesanddescribethepathologicfeaturesofeach.5.Listtheprognosti

3、cfactorsforbreastcancer.3医学课件BENIGNBREASTDISEASE7医学课件INFLAMMATIONAcuteMastitisMostclinicallyimportantformofmastitisBreast-feedingcracks/fissuresinthenipplesbacterialinfection(esp.Staph.aureus)8医学课件INFLAMMATIONAcuteMastitisUsuallyunilateral—acuteinflammationinthebreastcanleadtoab

4、scessformationTreatment=surgicaldrainage(oftenundergeneralanesthesia)andantibiotics9医学课件INFLAMMATIONMammaryDuctEctasia5thand6thdecadesAffectsmainlylargeductsPeriductalchronicinflammationdestructionanddilationoftheductswithfibrosisTheunderlyingcauseisunknown10医学课件INFLAMMATIONMamma

5、ryDuctEctasiaPoorlydefinedperiareolarmass;canbeconfusedclinically/radiologicallywithcarcinomaCanalsopresentasathick,cheesynippledischarge+/-massPeriductalfibrosisskinretraction11医学课件INFLAMMATIONFatNecrosisUncommonlesion;maybeahistoryoftrauma,priorsurgicalinterventionorradiationthe

6、rapyCharacterizedbyacentralfocusofnecroticfatcellswithlipid-ladenmacrophagesandneutrophils12医学课件INFLAMMATIONFatNecrosisChronicinflammationwithlymphsandmultinucleatedgiantcellsMajorclinicalsignificanceisitspossibleconfusionwithcarcinoma(e.g.fibrosisclinicallypalpablemass/Ca2+seeno

7、nmammography)13医学课件NON-PROLIFERATIVE(“FIBROCYSTIC”)CHANGESMostcommonbreastdisorderAlterationspresentinmostwomenNoassociatedriskofprogressionorcancer?Duetohormonalimbalances14医学课件NON-PROLIFERATIVE(“FIBROCYSTIC”)CHANGESPathologicfeatures:CysticchangeApocrinemetaplasiaAdenosisFibrosis

8、15医学课件16医学课件17医学课件N