调节性B细胞ppt课件.ppt

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1、Bregs-----RegulatoryBcells.Introduction1CluestoBregsexistence2Developmentanddifferentiation34ContentsPhenotypicalIdentification6BregsindiseasesFunctionofBregs5.IntroductionTraditionally,B cellshavebeenthoughttocontributetodiseasethroughproductionofantibodiesInthepasttwodecades,i

2、nvestigatorshaveattributedadditionalfunctionstoBcells,includingantigenpresentation,theproductionofmultiplecytokinesRecently,theabilityofB cellstonegativelyregulatecellularimmuneresponsesandinflammationhasbeendescribedandtheconceptofregulatoryB cellshasemerged..CluestoBregsexiste

3、nce199620021974BcellssuppressDTHsuppressorBcellscouldregulatetheimmuneresponseIL-10-producingBcellsregulateautoimmunityCD19+CD1dhiBcellsproducingIL-10controlTh2-drivencolitistheterm“regulatoryBcells”,whichdefinesB-cellsubsetswithregulatoryproperties,wasfirstintroducedBcell–defici

4、entmicedevelopchronicEAEBcellscouldrestraintheseverityofautoimmunedisease1980antigen-activatedBcellscouldinducetoleranceinrecipientnaivemiceSupporta‘suppressiveframework’forBcellsandintroducealinkwithT-celltolerance.DevelopmentandDifferentiationBcellB2B1在骨髓发育，分布外周淋巴器官，参与特异性免疫定位于

5、大网膜、胸腔及肠黏膜固有层，参与非特异性免疫.DevelopmentandDifferentiationFOBcellT2–MZPBcellMZBcellLeBienTW,TedderTF.Blymphocytes:howtheydevelopandfunction.Blood.2008.DevelopmentandDifferentiation.DevelopmentandDifferentiationMauriC,EhrensteinMR.The'short'historyofregulatoryBcells.TrendsImmunol.2008.

6、DevelopmentandDifferentiationMauriC,EhrensteinMR.The'short'historyofregulatoryBcells.TrendsImmunol.2008.DevelopmentandDifferentiationMizoguchiA,BhanAK.AcaseforregulatoryBcells.JImmunol.2006.PhenotypicalIdentificationHeY.TherolesofregulatoryBcellsincancer.JImmunolRes.2014..Phenot

7、ypicalIdentificationMauriC.ImmuneregulatoryfunctionofBcells.AnnuRevImmunol.2012.PhenotypicalIdentificationMauriC.ImmuneregulatoryfunctionofBcells.AnnuRevImmunol.2012.PhenotypicalIdentificationBodhankarS.IL-10-producingB-cellslimitCNSinflammationandinfarctvolumeinexperimentalstro

8、ke.MetabBrainDis.2013.PhenotypicalIdentificatio