《调节性B细胞》PPT课件.ppt

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1、Bregs-----RegulatoryBcellsIntroduction1CluestoBregsexistence2Developmentanddifferentiation34ContentsPhenotypicalIdentification6BregsindiseasesFunctionofBregs5IntroductionTraditionally,B cellshavebeenthoughttocontributetodiseasethroughproductionofantibodiesInthepasttwodec

2、ades,investigatorshaveattributedadditionalfunctionstoBcells,includingantigenpresentation,theproductionofmultiplecytokinesRecently,theabilityofB cellstonegativelyregulatecellularimmuneresponsesandinflammationhasbeendescribedandtheconceptofregulatoryB cellshasemerged.Clues

3、toBregsexistence199620021974BcellssuppressDTHsuppressorBcellscouldregulatetheimmuneresponseIL-10-producingBcellsregulateautoimmunityCD19+CD1dhiBcellsproducingIL-10controlTh2-drivencolitistheterm“regulatoryBcells”,whichdefinesB-cellsubsetswithregulatoryproperties,wasfirst

4、introducedBcell–deficientmicedevelopchronicEAEBcellscouldrestraintheseverityofautoimmunedisease1980antigen-activatedBcellscouldinducetoleranceinrecipientnaivemiceSupporta‘suppressiveframework’forBcellsandintroducealinkwithT-celltoleranceDevelopmentandDifferentiationBcellB

5、2B1在骨髓发育，分布外周淋巴器官，参与特异性免疫定位于大网膜、胸腔及肠黏膜固有层，参与非特异性免疫DevelopmentandDifferentiationFOBcellT2–MZPBcellMZBcellLeBienTW,TedderTF.Blymphocytes:howtheydevelopandfunction.Blood.2008DevelopmentandDifferentiationDevelopmentandDifferentiationMauriC,EhrensteinMR.The'short'historyofreg

6、ulatoryBcells.TrendsImmunol.2008DevelopmentandDifferentiationMauriC,EhrensteinMR.The'short'historyofregulatoryBcells.TrendsImmunol.2008DevelopmentandDifferentiationMizoguchiA,BhanAK.AcaseforregulatoryBcells.JImmunol.2006PhenotypicalIdentificationHeY.TherolesofregulatoryB

7、cellsincancer.JImmunolRes.2014.PhenotypicalIdentificationMauriC.ImmuneregulatoryfunctionofBcells.AnnuRevImmunol.2012PhenotypicalIdentificationMauriC.ImmuneregulatoryfunctionofBcells.AnnuRevImmunol.2012PhenotypicalIdentificationBodhankarS.IL-10-producingB-cellslimitCNSinf

8、lammationandinfarctvolumeinexperimentalstroke.MetabBrainDis.2013PhenotypicalIdentificationThereisnouniq