药理学课件：概论.ppt

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1、第六编药物治疗学基础SectionVIPharmacologicalbasisofdrugtherapeuticsGeneralPrinciplesGeneralConceptsHistoryTheNatureofDrugsMethodologyofPharmacologyNewDrugResearchandDevelopmentGeneralConceptsHumandisease:preventionandtreatmentDrugtherapySurgeryRadiotherapyPhysicalth

2、erapyPsychologicaltherapy药理学是药物治疗学的基础理论GeneralConceptsPharmacologycanbedefinedasthestudyofsubstancesthatinteractwithlivingsystemsthroughchemicalprocesses,especiallybybindingtoregulatorymoleculesandactivatingorinhibitingnormalbodyprocesses.MedicalPharmacolo

3、gyisoftendefinedasthescienceofsubstancesusedtoprevent,diagnose,andtreatdisease.－KatzungBG(Ed).Basic&ClinicalPharmacology(11thEdition).NewYork:McGraw-Hill,2010.药理学是研究药物与机体（包括人体和病原体）相互作用的规律及其原理，是一门为临床合理用药防治疾病提供基本理论的医学基础学科。WhatisPharmacologystudied?Pharmacody

4、namics（药效动力学，药效学）:theactionsofthedrugonthebodyandthemechanismsPharmacokinetics（药代动力学，药动学）:theactionsofthebodyonthedrugsFactors（影响因素）：influencingtheprocessesofpharmacodynamicsandpharmacokineticsDrugsHumanBodyPharmacodynamics（药效学）ActionandmechanismPharmacoki

5、netics（药动学）Absorption,distribution,metabolism,excretion,anddrugconcentrationinthebodyInteractionbetweendrugandhumanbody药物与人体的相互作用HumanPathogensDrugInteractionsbetweendrug,humanbody,andpathogens药物、人体和病原体之间的相互作用Pharmacy药学Pharmacology药理学Therapeutics治疗学BasicRe

6、search基础研究NewDrug新药研制ClinicalPharmacologyLifeScienceScreeningandEvaluationTheGoalsofPharmacologyDrugsHistoryRemediesinChinaandEgypt,recognizedandrecordedthebeneficialandtoxiceffectsofmanyplantandanimalmaterials.>2500yearsago～17thcentury.—本草学Materiamedica,t

7、hescienceofdrugpreparationandthemedicaluseofdrugs:theprecursorpharmacology.Endof17thcetury～18thcentury.——药物学2HistoryTraditionalpharmacology:developingthemethodsofexperimentalphysiologyandpharmacology;advancesinchemistry.18thcentury～earlyof20thcentury.——经典药

8、理学Modernpharmacology:conceptsofrationaltherapeutics,especiallythatofthecontrolledclinicaltrials;amajorexpansionofresearcheffortsinallareasofbiology,20thcentury～;rapidgrowthofinformationandunderstandingofthemo