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1、金属有机化学-均相催化,2010-11-18龚流柱中国科学技术大学合肥微尺度物质科学国家实验室,化学系CatalyticCross-CouplingReactionsChallengeintheActivationofInactiveChemicalBonds(C-X)SolutionstotheChallengeinPalladium-CatalyzedCrossCouplingReactionsElectron-RichandBulkyPhosphorusLigandsSuzukiCouplingofUnactivatedArylChlorideCatalyzedbyPa
2、lladiumShen,W.TetrahedronLett.1997,38,5575Firooznia,F.;Gude,C.;Chan,K.;Satoh,Y.TetrahedronLett.1998,39,3985Old,D.W.;Wolfe,J.P.;Buchwald,S.L.J.Am.Chem.Soc.1998,120,9722Wolfe,J.P.;Buchwald,S.L.Angew.Chem.Int.Ed.1999,38,2413Wolfe,J.P.;Singer,R.A.;Yang,B.-H.;Buchwald,S.L.J.Am.Chem.Soc.1999,121,
3、9550Littke,A.F.;Fu,G.C.Angew.Chem.Int.Ed.1998,37,3387Littke,A.F.;Dai,C.;Fu,G.C.J.Am.Chem.Soc.2000,122,4020Li,Y.-G.Angew.Chem.Int.Ed.2001,40,1513Ackermann,L.;Born,R.Angew.Chem.Int.Ed.2005,44,2444Zhang,C.;Huang,J.;Trudell,M.L.;Nolan,S.P.J.Org.Chem.1999,64,3804Forareview,see:Würtz,S.;Glorius,F
4、.Acc.Chem.Res.2008,41,1523Yin,J.;Buchwald,S.L.J.Am.Chem.Soc.2000,122,12051Water-SolubleLigandsAnderson,K.W.;Buchwald,S.L.Angew.Chem.Int.Ed.2005,44,6173RoomTemperatureSuzukiCouplingofArylchloridewithPolymerLigandsHu,Q.-S.;Lu,Y.;Tang,Z.-Y.;Yu,H.-B.J.Am.Chem.Soc.2003,125,2856Disassociatationof
5、Aryl-OxygenBondTang,Z.-Y.;Hu,Q.-S.J.Am.Chem.Soc.2004,126,3058Cross-CouplingofArylPivalateswithBoronicAcidswithNickelComplexesQuasdorf,K.W.;Tian,X.;Garg,N.K.J.Am.Chem.Soc.2008,130,14422TotalSynthesisofQuinineandQuinidineSyntheticApproachRaheem,I.T.;Goodman,S.N.;Jacobsen,E.N.J.Am.Chem.Soc.200
6、4,126,706OrganotrifluoboratesParticipateintheSuzukiCouplingReactionBarder,T.E.;Buchwald,S.L.Org.Lett.2004,6,2649StilleCouplingofUnactivatedArylChlorideLittke,A.F.;Fu,G.C.Angew.Chem.Int.Ed.1999,38,2411KumadaCouplingofUnactivatedArylChlorideKatayama,T.;Umeno,M.Chem.Lett.1991,2073KumadaCouplin
7、gofUnactivatedArylChlorideswithPd-CarbeneComplexesHuang,J.;Nolan,S.P.J.Am.Chem.Soc.1999,121,9889KumadaCouplingofUnactivatedArylChlorideswithNi-PhosphineOxidesAckermann,L.;Born,R.;Spatz,J.H.;Meyer,D.Angew.Chem.Int.Ed.2005,44,7216KumadaCouplingofUnactivate