防御素与急性肺损伤

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1、防御素与急性肺损伤DefensinsinAcuteLungInjuryDefinitionofALI&ARDSACCP/SCCM-Criteria,92AcuteonsetPaO2/FiO2<300forALI,<200forARDSBilateralparenchymalinfilatratesonchestradiographNoclinicalevidenceofleftatrialhypertensionDefinitionofSIRS,Sepsis,MODSACCP/SCCM-Criteria,91Sepsi

2、sBacteremiaFungemiaParasitemiaViremiaOtherOtherTraumaBurnsSIRSInfectionPancreatitisSIRSCARSMARSDefensinscysteine-richcationicantimicrobialpeptideswiththreedisulfidebridges-defensins(6)and-defensins(30)antimicrobialactivitychemotacticactivityformonocytes,immatu

3、redendriticcellsandmemoryTcellsvasculogenesisintumorsRoleofbeta-defensin-1inALIModel:Pneumonia&CLPinratIntervention:Recombinantadenoviruscarryingthegeneencoding-defensin-2,intratracheal,48hpriorMonitor:Bacteriaclear,inflammation(HE&ICAM),survivalratePathologica

4、lalterationoflungsCLPCLP&beta-defensin-2DetectionofICAMinlungCLPCLP&beta-defensin2LevelofICAM-1inLungtissueOpticaldensity(arbitraryunits)0122436721680.400.10.20.3GroupCGroupDTimeafterCLP(hour)**TimeafterALI(hours)10030509080407060RatswithAd.rBD2RatswithAd.VSurvi

5、valofadenovirus-pretreatedratsfollowingCLP24487296120144168HrsSurvival%ConclusionandFuture-defensin-2hadprotectiveroleinALI/ARDS,viabothantibacterialeffectandmodulationofinflammationTime-&Dose-dependentstudy,geneticassociationanalysiswillbehelpfulforthemechanis

6、mandfunctionofdefensinsinALI/ARDS.THANKSTSGZ0004-2007(1)基本格式统一封面、目录、鉴定评审结论、明细表(2)有关填写要求见附件G43谢谢大家观赏