cushingsyndrome分析课件

《cushingsyndrome分析课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、HYPERCORTISOLISMCUSHINGSYNDROMEContentsWhatisCushingsyndrome?Whatisthecauses?Howtodiagnose?ClinicalFeaturesHormonelevelsFunctionaltestLocalizationHowtotreatment?ContentsWhatisCushingsyndrome?Whatisthecauses?Howtodiagnose?ClinicalFeaturesHormonelevelsFunctionaltestLocalizationHowtotreatment?Definitio

2、nCushingSyndromeAdiversesymptomcomplexresultingfromexcesssteroidhormone(cortisol)productionCushingDiseaseAhypercortisolismresultingfrompituitaryACTHhypersecretionContentsWhatisCushingsyndrome?Whatisthecauses?Howtodiagnose?ClinicalFeaturesHormonelevelsFunctionaltestLocalizationHowtotreatment?CapsulaG

3、lomerulosaFasciculataReticularisMedullaAldosteroneAndrogenCatecholamineAdrenalStructureCortisolCortisolSecretionRegulationACTHCRHCortisolHypothalamusPituitaryAdrenalCausesofCushingSyndromeACTHCRHCortisolHypothalamusPituitaryAdrenalEctopicCRHsyndromeHypothalamusCushingsyn.Cushingdisease(CD)EctopicACT

4、HsyndromeAdrenaladenomaAdrenalcarcinomaMicronodularadrenaldiseaseMassivemacronodularadrenaldiseaseCausesofCushingsyndrome1.EndogenousCushingsyndrome(1)ACTH-dependentCushingdisease(CD)EctopicACTHsyndromeEctopicCRHsyndrome(2)ACTH-independentAdrenaladenomaAdrenalcarcinomaMicronodularadrenaldiseaseMassi

5、vemacronodularadrenaldisease(3)Pseudocushingsyndrome2.ExogenousCushingsyndromeContentsWhatisCushingsyndrome?Whatisthecauses?Howtodiagnose?ClinicalFeaturesHormonelevelsFunctionaltestLocalizationHowtotreatment?FunctionClinicalFeaturesFunctionsClinicalFeaturesFatCentralobesity,“moonface”“buffalohump”Pr

6、oteinThinextremities,muscleweakness,Purplestriae,bruising,osteoporosisGlucoseIGT,DMElectrolyteHypertension,hypokalemia,alkalosisFunctionsClinicalFeaturesImmunityInfection,impairedwoundhealingSexglandHirsutism,acne,menstrualdysfunction,ErectiledysfunctionBonemarrowIncreasedRBCandWBC，plethoricMentalIn

7、creasedlabilitySkinHyperpigmentationFunctionClinicalFeaturesHormoneLevel1.CortisollevelsPlasmacortisolrhythm(8Am,4Pm,midnight)24hUrinaryfreecortisol,17-OHCS,17-KSPlasmaACTHrhythm2.FunctionalTestsLowdo