合肥市包河区2～12岁儿童A、C群流脑抗体水平分析-论文.pdf

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1、皖南医学院学报(JofWannanMedicalCollege)2014；33(4·365··预防医学·文章编号：1002—0217(2014)04—0365—03合肥市包河区2～12岁儿童A、C群流脑抗体水平分析张成成，夏俊瑞，郑文榜，丁仁翠，赵瑞君(合肥市包河区疾病预防控制中心，安徽合肥230051)【摘要】目的：了解包河区2～12岁儿童A和C群流脑抗体水平，为制定流脑防控策略提供科学依据。方法：选择2011～2013年在包河区疾控中心进行抗体检测的984名儿童作为研究对象，询问儿童基本信息和流脑疫苗既往免疫史

2、，检测儿童A和c群流脑抗体阳性情况。结果：A群和C群流脑抗体阳性率分别为70．3％和87．1％，A群和C群流脑抗体阳性率分布性别、户籍地属性问差异无统计学意义(P>0．05)，而2～5岁儿童A、C群流脑抗体阳性率均高于6—12岁儿童，且差异有统计学意义(P<0．05)，按程序全程接种的儿童(A、C群流脑)抗体阳性率高于未全程接种者，接种2剂次A+C流脑结合疫苗+1剂次A+C流脑多糖疫苗者A群和C群流脑抗体阳性率高于接种2剂次A群流脑多糖疫苗+1剂次A+C流脑多糖疫苗。结论：适龄儿童按免疫程序完成2剂次A+c流脑结合

3、疫苗基础免疫和2剂次A+c流脑多糖疫苗加强免疫，方能达到最好预防效果。【关键词】儿童；流脑；抗体水平；阳性率【中图号】R512．3【文献标识码】A·【DOI】10．3969／j．issn．1002-0217．2014．04．026AnalysisoftheantibodylevelsofgroupAandCofepidemiccerebrospinalmeningitisinchil-drenoftwototwelveyearsinBaoheareaofHefeiCityZHANGChengcheng，XIAJun

4、rui，ZHENGWenbang，DINGRencui，ZHAORu~unBaoheCenterForDiseaseControlandPrevention，Hefei230051，China【Abstract】Objective：ToinvestigatetheantibodylevelsofgroupAandgroupCofepidemiceerebrospinalmeningitisinchildrenagedtwototwelveyearslivinginBaoheareaofHefeicity，China

5、forscientificevidencetoplanastrategYinpreventionandcontrolofthisepidemics．Methods：984children，under-gonedetectionofpositiveantibodyagainstmeningococcusinBaoheCenterforDiseaseControlandPreventionbetween2011and2013，wereincluded．De—mographicinformationandhistoryo

6、fvaccineforepidemicmenigitiswereinvestigated，andthepositiveantibodyagainstserogroupAandCwasmaintained．Results：PositiverateoftheantibodyagainstserogroupAandCofepidemiccerebrospinalmeningitiswas70．3％and87．1％，respectively，yetremainednostatisticaldifferenceregardi

7、ngthegendersandcensusregister(P>0．05)．PositiverateforserogroupAandCwashigherinchildrenagedtwotofiveyearsthanthoseofsixtotwelveyears，andthedifferencewassignificant(P<0．05)．Also，thepositiveratewashigherinchildrenreceivedcompletevacci·nationprotocolthanthosefaile

8、dto，andinthosereceiveddoubledosesofserogroupAandCvaccinesplusonedoseofAandCpolysaccharideswerehigherthanchildrenreceiveddoubledosesofserogroupAvaccinesplusonedoseofAandCpolysaechar