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时间:2020-04-21
《氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎65例的疗效评价-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国免疫学杂志2014年第30卷doi:10.3969/j.issn.1000-484X.2014.06.024氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎65例的疗效评价凌云杨春悦①杨红梅②(承德市双桥区人民医院,承德067000)中图分类号R765.21文献标志码A文章编号1000-484X(2014)06-0828-03[摘要]目的:观察盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎的临床疗效,为临床诊治过敏性鼻炎提供科学依据。方法:129例过敏性鼻炎患者,随机分为观察组和对照组,对照组患者给予盐酸氮卓斯汀鼻喷剂喷鼻,观察组在对照组基础上联合地氯雷他定5mg口服,
2、每晚1次,均4周为1个疗程。结果:观察组总有效率为93.85%,高于对照组的81.25%,两者有显著性差异(PO.05)。结论:盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎起效快、安全有效,可提高临床总有效率和改善患者的临床症状,值得临床推广应用。[关键词]盐酸氮卓斯汀;地氯雷他定;过敏性鼻炎;安全性;有效性Eficacyassessmenton65caseswithallergicrhinitistreatedbyazelastinehydro·chloridenasalspraycombined
3、withdesl0ratadineLINGYun,YANGChun—Yue,YANGHong—Mei.ShuangqiaoDistrictHospitalofChengde。Chengde067000,China[Abstract]Objective:Toprovidescientificbasisfortheclinicaldiagnosisandtreatmentofallergicrhinitisbyobservationofcurativeeffectoftreatmenttoallergicrhinitisbyazelastinehydrochloriden
4、asalspraycombinedwithdesloratadine.Methods:Onehundredandtwenty—ninepatientswithallergicrhinitiswererandomlydividedintotwogroups:anexperimentalgroupandacontrolgroup.Thecontrolgroupwastreatedbyazelastinehydrochloridenasalspray.Theexperimentalgroupwastreatedbyazelastinehydrochloridenasalsp
5、rayanddesloratadine5mgpernight.Oneperiodoftreatmentforeachgroupis4weeks.Results:thecurerateoftheexperimentalgroupwas93.85%and81.25%incontrolgroup,withagreatdifferencebetweenthem(P<0.05);Theincidencerateofadversedrugreactions(ADR)oftheformerandthelatterwere10.77%and7.81%(P>0.05).Conclusi
6、on:azelastinehydro—chloridenasalspraycombinedwithdesloratadinecantreatpatientswithallergicrhinitiseffectivelyandsafely.Itcanincreasethetotaleffectiverateandimprovepresent’Ssymptoms.Ithasgreatvalueinclinicalapplication.[Keywords]Azelastinehydrochlorid;Desforatadine;Allergicrhinitis;Safet
7、y;Eficacy过敏性鼻炎(Allergicrhinitis,AR)又名变应性病J。病程迁延,痛苦不堪,极大地影响了患者正鼻炎,是临床上常见的鼻部疾患,是发生在鼻黏膜的常的工作、学习和生活。选取64例过敏性鼻炎患者变态反应性疾病。鼻黏膜反应性增高是其主要特作为对照组,给予盐酸氮卓斯汀鼻喷剂喷鼻;在对照点⋯。近年来,过敏性鼻炎发病率明显上升,据统组基础上65例患者联合地氯雷他定5mg口服作为计,全世界有20%~30%的人深受变态反应性疾病观察组,进行对比分析,报告如下。的困扰,而且每年以1%的速度增加。WHO已1资料与方法将其列为2l世纪重点研究和防
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