血清同型半胱氨酸和高敏C反应蛋白与心血管疾病的相关性探讨.pdf

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1、·8·史垦堕压塞旦匿堂!!!垒生!旦箜i鲞筮!塑￡!i!!￡!也旦墼!丛塑：!!!型!垡垫!!!!!!：!：盟!：!·一心_tilt管·血清同型半胱氨酸和高敏C反应蛋白与心血管疾病的相关陛探讨王陆荣周涛刘婷芝成，J、英【摘要】目的探讨血清同型半胱氨酸(HCY)和高敏c反应蛋白(hs-CRP)在心血管疾病(CVD)诊疗中的临床价值。方法通过临床试验，检测210例CVD患者和190名健康人群中血清HCY浓度，同时检测hs．CRP，进行对比分析。结果CVD患者组(试验组)的血清HCY浓度主要集中在10—20IXmol／L，而健康

2、体检者(对照组)则为0。5IXmol／L；试验组的血清hs—CRP浓度主要集中在2—15mg／L，而对照组则为0—8mg／L；试验组HCY浓度平均值为19．6¨mol／L，明显高于对照组的9．4IXmol／L，而试验组hs—CRP浓度平均值为8．4mg／L，也明显高于对照组的1．3mg／L，两组在血清HCY和hs—CRP这两项指标上存在高度一致性，且数据集中趋势比较明显。结论综合监测血清中HCY和hs．CRP浓度的变化，对心血管疾病诊疗有十分重要的临床价值。【关键词】同型半胱氨酸；高敏c反应蛋白；心血管疾病；冠心病Expl

3、orethecorrelationofserumhomocysteineandhigh-sensitiVityC-reactiveproteinwithcardiovasculardiseaseWangLurong’，ZhouTao，LiuTingzhi，ChengXiao-ying．"FenggangHospitalofDongguan，Dongguan523681，ChinaCorrespondingauthor：ZhouTao，Email：chriszhou2002@163．corn【Abstract】objecti

4、veDiscusstheclinicalvalueofserumhomocysteine(HCY)andhigh—sensitivityC—reactiveprotein(hs—CRP)inthediagnosisandtreatmentofcardiovasculardisease(CVD)．MethodsThroughtheclinicaltest，theserumHCYconcentrationandhs—CRPconcentrationof210casesofCVDpatientsand190casesofheal

5、thypeoplesweretestedandcompared．ResuitsForserumHCY．theCVDpatientgroup(experimentalgroup)concentratemainlyontheof10-20斗mol／L，andhealthyrangegroup(controlgroup)concentratemainlyontherangeof0-5斗mol／L，forScnlmhs—CRP，theconcentrationoftheexperimentalgroupconcentratemai

6、nlyontherangeof2-15mg／L，whiletheconcentrationofthecontrolgroupconcentratemainlyontherangeof0-8mg／L，theaverageconcentrationofexperimentalgroupHCYis19．6“mol／L，significantlyhigherthan9．4斗mol／Lofcontrolgroup；theaverageconcentrationofexperimentalgrouphs—CRPis8．4mg／L，si

7、gnificantlyhigherthan1．3mg／Lofcontrolgroup，thereisahighdegreeofconsistencyinserumHCYandhs·CRPoftwogroups，andthecentraltendencyofthedataismoreobvious．ConclusionThroughcomprehensivemonitoringofserumHCYandhs—CRPconcentration，ithasimportantclinicalvalueforthediagnosis

8、andtreatmentofcardiovasculardisease．【Keywords】Homocysteine；High-sensitivityC-reactiveprotein；Cardiovasculardisease；Coronarydisease近年来，随着人们生活水平的提高和生活方式的逐