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《research projects july 1, 2007 june 30, 2008》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、RESEARCHPROJECTSJULY1,2007–JUNE30,2008ProjectTitle:ActivityofNemonoxacinagainstthe197MRSAfromourCANICUstudyaswellasthe18MRSAfromtheNARSAcollectionPI:Dr.G.G.ZhanelCo-PI:Dr.D.J.Hoban;Collaborators:Dr.M.R.Mulvey,NationalMicrobiologyLaboratoryProjectDescription:Toassesstheac
2、tivityofanewquinolone-nemonoxacinagainst197MRSAfromtheCANICUstudy.Toassesstheactivityofanewquinolone-nemonoxacinagainst18MRSAfromtheNARSAcollection.FundingSource(s):TaiGenBiotechnologyCompany,Ltd.,Taiwan;TotalFundingAmount:$10,000Duration:6monthsProjectTitle:ActivityofTi
3、gecyclineandComparatorsagainst475ClostridiumdifficileobtainedthroughoutManitobaPI:Dr.G.G.Zhanel;Co-PI:Dr.D.J.Hoban;ProjectDescription:TodeterminetheactivityoftigecyclineandvariouscomparatorsagainstC.difficileobtainedthroughoutManitoba;FundingSource(s):WyethPharmaceutical
4、s;TotalFundingAmount:$11,250;Duration:9monthsProjectTitle:AgronomicpracticestolimitthesurvivalinsoilofpotentialhumanpathogensfromlivestockmanurePI:Krause,Denis,IvanOresnik,andMarioTenuta;ProjectDescription:Asabove;FundingSource(s):ManitobaAssociationofAgriculturalSocieti
5、es/ARDI;TotalFundingAmount:$70,953;Duration:2007–2010ProjectTitle:AlterationofAPOBEC3GvirionincorporationpathwayleadstoHIV-1inactivationinthepresenceofVif:Developmentofanovelanti-HIVstrategyPI:XiaojianYao;ProjectDescription:APOBEC3G(A3G),adeoxycytidinedeaminase,isapowerf
6、ulhostantiviralfactorthatisrecentlyfoundtobeabletorestrictHIV-1infection.IthasbeenshownthatthishostproteinisabletotargetintoHIV-1particlesandactstomutateviralDNAaswellastoinhibitHIV-1reversetranscriptionsoonaftervirusinvadesintocells.However,althoughthishostproteinholdsp
7、otentantiviralpotentials,itsactioniscounteractedbyaHIV-1Vifprotein.MechanisticstudieshaverevealedthatHIV-1VifiscapableofinteractingwithA3G,andconsequentlyinducesitsdegradationandpreventsA3Gtobeincorporatedintoviralparticles.DuetothefactthathostA3Gexertsapotentanti-HIVact
8、ivitywhichwasblockedbyHIV-1Vif,thiscellular/viralproteininteractionisofconsiderableinterest,asitprovide
