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1、·34·上海中医药杂志2011年第45卷第3期SH.J.TCMMar.,2011;Vol.45No.3健脾温阳法治疗慢性乙型肝炎肝纤维化临床研究1,22223郝瑞春,门九章,李孝波,李霞,吕建军1.湖北中医药大学2008级博士班(湖北武汉430065);2.山西中医学院(山西太原030024);3.山西生物应用职业技术学院中药系(山西太原030031)【摘要】目的观察健脾温阳法治疗慢性乙型肝炎肝纤维化的临床疗效。方法30例慢性乙型肝炎肝纤维化患者均采用以温阳健脾立法的雄芍汤治疗,疗程为6个月;评价临床疗效,观察治疗前后症状体征、肝功能指标、血清肝纤维化指标(HA、PCⅢ、IV2
2、C、LN)及肝脾B超的变化情况。结果总有效率为93.3%;除肝脏B超疗效不明显外,患者症状和体征、肝功能、肝纤维化指标、脾脏厚度、门静脉直径均有明显改善(P<0.01,P<0.05)。结论雄芍汤对脾肾阳虚型慢性乙型肝炎肝纤维化有较好疗效,可保护肝细胞、改善肝功能,并有抗肝纤维化作用。【关键词】慢性乙型肝炎;肝纤维化;中医药疗法;健脾温阳;临床研究++【中图分类号】R512.62;R657.31【文献标志码】A【文章编号】100721334(2011)0320034203Clinicalstudyontherapeuticmethodofspleen2strengtheninga
3、ndyang2warmingtherapyforhepaticfibrosisfollowingchronichepatitisB1,22223HAORui2chun,MENJiu2zhang,LIXiao2bo,LIXia,LUJian2jun1.Class2008PhD,HubeiUniversityofTraditionalChineseMedicine;2.DepartmentofTraditionalChineseMedicine,ShanxiCollegeofTraditionalChineseMedicine;3.DepartmentofChineseMateri
4、aMedica,ShanxiInstituteofBiologicalAppliedTechnologyAbstract:ObjectiveToobserveclinicaleffectsofspleen2strengtheningandyang2warmingtherapyforhepaticfibrosisfollowingchronichepatitisB.MethodsThirtypatientswithhepaticfibrosisduetochronichepatitisBweretreatedwith“XiongshaoDecoction”tostrengthen
5、spleenandwarmyangfor6months.Clinicalcurativeeffectwereestimated.Beforeandaftertreatment,clinicalsymptomsandsignswereobserved,andliverfunction,serummarkersofhepaticfibrosis(HA,PCⅢ,C2IV,LN)andB2modeultrasoundofliverandspleenweredetermined.ResultsThetotaleffectiveratewas93.3%.Besidesthechangeof
6、B2modeultra2soundofliver,theclinicalsymptomsandsigns,liverfunction,serummarkersofhepaticfibrosis,spleendepthandportalveindiameterimprovedsignificantly(P<0.01,P<0.05).Conclusion“XiongshaoDecoction”hasapparentcurativeeffectonhepaticfibrosisfollowingchronichepatitisBofspleen2kidneyyangdeficienc
7、y,andcanprotectlivercellsfromdamage,improvehepaticfunctionandfightagainsthepaticfibrosis.Keywords:ChronichepatitisB;hepaticfibrosis;Chinesemedicine;strengtheningspleenandwarmingyang;clinicalstudy肝纤维化是指肝脏内纤维结缔组织异常增生的病1资料与方法理过程。由于多种慢性肝病均可发生肝纤维化,而肝1.1
