从基因到天然产物生物合成课件.ppt

《从基因到天然产物生物合成课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、There‑emergenceofnaturalproductsfordrugdiscoveryinthegenomicsera药物基因组学教研室解鸿波NaturalproductsanddrugdiscoveryNaturalproductsandgenomicsFuturedirectionsandoutlookSourcesofNaturalproducts1234Whatarenaturalproducts?1.SourcesofNaturalproductsWhatarenaturalprodu

2、cts?1.SourcesofNaturalproductsArtemisinin2.NaturalproductsanddrugdiscoveryMorphineQuininePaclitaxel6%27%25%5%37%AllsmallmoleculenewchemicalentitiesCommerciallyavailablechemicalspace22x106compoundsNaturalproductuniverse16x104compoundsNatural-productdatabas

3、esDatabaseNumberofentriesAdditionalinformationSuperNaturalII355,0002DstructureswithvendorinformationUniversalNaturalProductDatabase197,2013DstructuresassembledfromotherdatabasesChineseNaturalProductDatabase53,000HasbeenusedinvirtualscreeniSMART20,000Fromt

4、raditionalChinesemedicinesAfroDb1,000FromAfricanmedicinalplantsInteractionsbetweendrugandtarget3.NaturalproductsandgenomicsInsightsintotheBiosynthesisInsightsintotheBiosynthesisGeneclusterBioinformaticstoolsantiSMASH3.0DiscovernewdrugleadsDiscovernewdrugl

5、eadsPromoterreplacementsandgenedeletions4.Futuredirectionsandoutlook“Therewasanintrinsicbeliefinthevalueofthemoleculeswe'reseeking.”–GregoryVerdine