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ID:57198152
大小:7.82 MB
页数:26页
时间:2020-08-03
《从基因到天然产物生物合成课件.ppt》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、There‑emergenceofnaturalproductsfordrugdiscoveryinthegenomicsera药物基因组学教研室解鸿波NaturalproductsanddrugdiscoveryNaturalproductsandgenomicsFuturedirectionsandoutlookSourcesofNaturalproducts1234Whatarenaturalproducts?1.SourcesofNaturalproductsWhatarenaturalprodu
2、cts?1.SourcesofNaturalproductsArtemisinin2.NaturalproductsanddrugdiscoveryMorphineQuininePaclitaxel6%27%25%5%37%AllsmallmoleculenewchemicalentitiesCommerciallyavailablechemicalspace22x106compoundsNaturalproductuniverse16x104compoundsNatural-productdatabas
3、esDatabaseNumberofentriesAdditionalinformationSuperNaturalII355,0002DstructureswithvendorinformationUniversalNaturalProductDatabase197,2013DstructuresassembledfromotherdatabasesChineseNaturalProductDatabase53,000HasbeenusedinvirtualscreeniSMART20,000Fromt
4、raditionalChinesemedicinesAfroDb1,000FromAfricanmedicinalplantsInteractionsbetweendrugandtarget3.NaturalproductsandgenomicsInsightsintotheBiosynthesisInsightsintotheBiosynthesisGeneclusterBioinformaticstoolsantiSMASH3.0DiscovernewdrugleadsDiscovernewdrugl
5、eadsPromoterreplacementsandgenedeletions4.Futuredirectionsandoutlook“Therewasanintrinsicbeliefinthevalueofthemoleculeswe'reseeking.”–GregoryVerdine
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