[摘要]目的 观察医用臭氧不同注射方式对兔腰椎间盘正常髓核.doc

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1、［摘要］目的观察医用臭氧不同注射方式对兔腰椎间盘正常髓［摘要］口的观察医川臭氧不同注射方式对兔腰椎间盘正常髓核的作用以及安全性。方法家兔20只，于透视下川20G儿童穿刺针刺入家兔腰椎间盘中心部，抽取5ml浓度为40ug/ml臭氧,经穿刺针注入3ml,在椎间孔处将剩余气体注入椎旁组织。其屮L4-5为椎间盘内单点注射，L5-6为椎间盘内多点注射，以L3-4椎间盘作为正常对照。20只兔注射臭氧1次,分别在术后1周、2周、3周、4周后处死取标木，将实验和正常对照标木屮椎间盘髓核作人体、光镜下观察，并对光镜下髓核内细胞计数行统计学分析。结果术后实验动物均无严重的行为异常。各于•

2、术腰椎间盘术后1周腰椎间盘髓核水分明显减少，外形萎缩,4周髓核T•涸，完全呈灰门色T•酪样。多点注射组髓核内细胞计数比较单点注射组明显减少，两考差异具有显著性。结论木研究显示椎间盘内40ug/ml臭氧注射安全性较好，臭氧对髓核缓慢萎缩作川多点注射强于单点注射方式,为该技术在临床的应川提供了实验依据。【关键词】椎间盘；臭氧；放射学，介入性；动物，实验，多点Percutaneousintradiscaloxygen-ozone(03)multipointinjection:anexperimentalstudyinconesJiangJianwci,WuQinghua,W

3、uZhenhai,LiXinsheng,ChengGang,GuChonInterventionalRadiology,uuxiBHospital,Wuxi510515,China［Abstract】ObjectiveToevaluatetheinfluenceofoxygen-ozoneonnormalnucleuspulposusinconesandthesafetyofintradiscaloxygen-ozonemultipoint.injectionforthetreatmentofherniatedlumbardisc.MethodsOxygen-ozon

4、eat40ug/mlwasinjectedintoselectedlumbardiscs(3ml)andtheparaspinalspace(2ml)with20GChibaneedleunderfluoroscopyintwentycones.EveryconewasgivenmultipointinjectioninL5-6andonepointinjectionin1,4一5respectively.Thewholeconesweregivenonetimeoxygenozoneinjectionandweresacrificedforpathologyono

5、week,twoweeks,threeweeksandfourweeksrespectivelyaftertheprocedure,specimensinnucleuspulposuswasobservedmacroscopicallyandmicroscopically.ResultsNoseriousbehaviorabnormalitieswereobservedinal1animals.Theatrophyofnucleuspulposuscouldbeobservedoneweekafteroxygen-ozoneinjectionduetosignific

6、antreductionofwater・Thenueleuspulposusturnedtodryupandlookedlikegraycheesesafterfourweeks.Therewasapparentdifferenceonthece11countingofrmcleuspulposusbetweentheselectedL4-5andL5-6intervertebraldisc.thecellcountingofnucleuspulposusinL5-6intervertebraldiskdecreaseobviously.ConelusionItiss

7、uggestedthatpercutaneousintradisealoxygen-ozoneinjectionat40ug/mlisasafemethod,andcancausegradualatrophyofnucleuspulposus・Theeffectonatrophyofnucleuspulposusbymultipointinjectionmodelisbetterthanbyonepointinjection.Thisstudyprovidestheevidenceofthefeasibilityandvalueofthisproce