清肺除刺方对金黄地鼠皮脂腺斑组织形态的影响.pdf

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1、710浙江中西医结合杂志2013年第23卷第9期ZhejiangJITCWM(Vo1．23No．92013)·实验研究·清肺除刺方对金黄地鼠皮脂腺斑组织形态的影响郭潋李咏梅上海中医药大学附属龙华医院皮肤科上海200032李淑上海市嘉定区中医医院皮肤科陈毅丽上海市嘉定区安亭医院皮肤科摘要目的：观察清肺除刺方对金黄地鼠皮脂腺斑组织形态的影响，探讨其对皮脂腺分泌的干预作用。方法：选用金黄地鼠背部的皮脂腺斑作为动物模型。24只金黄地鼠随机分成清肺除刺方组、维胺酯组和对照组，每组8只。分别给予清肺除刺方溶液(1．3mL／d)、维胺脂混悬液(1．3mUd，浓度1mg，mL)和生理盐水(

2、1．3mL／d)灌胃，连续28天。用游标卡尺测量背部右侧皮脂腺斑的最大横径(DT)和最大纵径(DL)，光镜观察皮脂腺斑的显微结构。结果：与对照组比较，清肺除刺方组地鼠背部皮脂腺斑面积明显缩小(P<0．05)，背部皮脂腺斑厚度明显变薄(尸<0．05)；与维胺酯组比较，差异无统计学意义(P>0．05)；光镜下，清肺除刺方组和维胺酯组地鼠皮脂腺厚度较薄，多为l～2层，皮脂腺排列松散，腺叶较小，液化小囊形成数目较多；对照组地鼠皮脂腺呈分叶状分布，排列较紧较厚(重叠腺叶数>14个)，部分腺叶大而饱满。结论：清肺除刺方对金黄地鼠皮脂腺分泌具有抑制作用，能够改善皮脂腺增厚、腺体排列紧密的

3、组织形态。关键词金黄地鼠皮脂腺斑组织病理学清肺除刺方EfectofQingfeichuciPrescriptiononSebaceousGlandSpotMorphologyofGoldenHamstersGUOIjian．LIShu．CHENYili，eta1．TheAj~liatedLonghuaHospitdofShanghaiUniversityofTraditionalChineseMedicine，Shanghai(200032)，ChinaAbstract0bjecfive：ToobservetheeffectofQingfeiehueiprescriptio

4、nonsebaceousglandspotofgoldenhamsters．Methods：Goldengopherssebaceousglandswasusedasanimalmode1．Thegoldenhamsterswererandomlydividedinto3groups：Qingfeiehuciprescriptiongroup(1．3ml／d)，viaminategroup(1．3ml／d，ataconcentrationoflmg／m1)，andcontrolgroup(saline1．3ml／d)．Alltreatmentsweregivenfor28d

5、ays．Sebaceousglandsofallratsweremeasuredwithverniercaliperattherightspotincludingthebiggestdiameterandthemaximumlongitudinaldiameter．Themicroscopicstructureofsebaceousglandswereobservedunderli曲tmicroscope．Results：Comparedwiththecontrolgroup，theareaandthicknessofspotsintheQingfeichuciprescr

6、iptiongroupwassignificantlysmallerandthinner(PO．05)．Histologicalobserv~ionrevealedthatoneortwolayersofsebaceousglandinthedrugandviaminategroups，witharrangementloosened，smallerlobes，andmorecolliquativecavities，whilelobulatedsebaceous

7、glandinthecontrolgroupwithmorethan4overlappinglobes．Conclusion：QingfeichuciprescriptionhadinhibitoryefectsongoldenhamsterSsebaceousglandsecretion，whichcanimprovetheabnormalmorphologyofsebaceousglands．KeywordsgoldenhamstersebaceousglandspothistopathologyQingfei