欢迎来到天天文库
浏览记录
ID:55977064
大小:843.25 KB
页数:4页
时间:2020-06-03
《抑郁症大鼠海马 BDNF 及其受体 TrkB 和p75NTR 的表达及米氮平的调节作用.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、脑与神经疾病杂志2014年第22卷第3期161·论著·抑郁症大鼠海马BDNF及其受体TrkB和p75NTR的表达及米氮平的调节作用董玉霞孙晓红何悦杨洋姜源马超刘晓楠李慧源【摘要】目的观察抑郁症模型大鼠学习记忆力改变情况,研究海马脑源性神经营养因子(BDNF)、酪氨酸激酶受体B(TrkB)和神经营养因子低亲和力受体(p75NTR)蛋白的表达变化,以及米氮平的调节作用。方法制备抑郁症大鼠模型;采用Morris水迷宫实验方法记录大鼠游动距离变化;免疫组化染色方法测定海马BDNF、TrkB和p75NTR表达阳性区吸光度值。
2、结果抑郁症模型大鼠在目标象限游动距离减少,海马BDNF及TrkB蛋白表达减少,p75NTR蛋白表达增加;米氮平逆转上述行为学异常及蛋白表达异常(P<0.01)。结论抑郁症模型大鼠可能存在BDNF-p75NTR通路信息传递增强,而抗抑郁治疗用药可能通过BDNF-TrkB信号通路的改变引起相应行为学改善。【关键词】慢性应激抑郁;海马;脑源性神经营养因子;酪氨酸激酶受体B;神经营养因子低亲和力受体中图分类号:R743文献标识码:A文章编号:1006-351X(2014)03.161—04Theexpressionofhi
3、ppocampalBDNF,TrkBandp75NTRindepressionmodelratsandtheefectsofmirtazapineDONGYu—xia,SUNXiao一,,,HEYue,YANGYang,JIANGYuan,MAChao,LIUXiao—nan,LIHui—yuan.DepartmentofNeurology,theFourthAfiliatedHospitalofChinaMedicalUniversity,Shenyang11(}032,ChinaCorrespondingaut
4、hor:SUNXiao—hong,Email:sunx/aohong1972@hotmail.com【Abstract】ObjectiveThisstudyistoevaluatethechangesoflearningandmemoryabilityandtheexpressionofbrain-derivedneurotrophicfactor,trkreceptortyrosinekinase,andthep75nettrotrophinreceptorinhippocampusofdepressiverat
5、s,andtoexploretheundedingregulationofmirtazapine.MethodsRatmodelswerecreatedbychronicunpredictablestress;Morriswatermazetestwasusedtorecordtheswimlengthsvarity;ImmunohistochemistrywereconductedtoassaythelevelsofBDNF,TrkB,andp75NTRproteinsinthehippocampus.Resul
6、tsInthedepressiongroup,swimlengthsinthetargetquadrantWasdecreased;theBDNFandTrkBproteinlevelswerelower,whereasp75NTRproteinlevelWashigher.Mirtazapinetreatmentreversedtheaboveabnormality.ConclusionChronicunpredictablestressmayharmlearningandmemoryabilitythrough
7、BDNF—p75NTRpathway,whereasmirtazapineimprovestheimpairmentthroughBDNF-TrkBpathway.【Keywords】Chronicunpredictablestress;Hippocampus;Brain-derivedneurotmphicfactor;Trkreceptortyrosinekinase;Thep75neurotrophinreceptor脑源性神经营养因子(brain-derivedneurotmphickinase,TrkB)
8、和神经营养因子低亲和力受体(thep75factor,BDNF)是神经营养因子家族内分泌蛋白中的一neurotrophinreceptor,p75NTR),对细胞存活及突触可塑种,BDNF发挥其生物学作用有赖于其特异性与两类不同性起调节作用J。体内BDNF先合成脑源性神经营养因的跨膜受体结合,酪氨酸激酶受体B(trkreceptortyrosine子前体蛋白
此文档下载收益归作者所有