VEGF、CD34、Ki-67和p21在翼状胬肉中的表达及意义.pdf

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1、IntEyeSci，Vo1．14，No．7，Ju1．2014www．ies．net．caTel：029-8224517282210956Email：UO．2000@163．com作者单位：(215300)中国江苏省昆山市第一人民医院眼科；VEGFandKi一67(r=0．279，P<0．05)，apositive病理科correlationbetweenVEGFandCD34(r=0．299，P<0．05)，作者简介：王丽波，硕士，副主任医师，研究方向：眼表疾病、屈anegativecorrelationbetweenVEGFandp21(

2、r=一0．267．光手术及眼底疾病。P<0．05)：itaIsoshowedthattherewasnocorrelation通讯作者：王丽波．zhoujianwanglibo@163．coinbetweenanytwoofCD34．Ki一67andp21(P>0．05)．收稿Et期：2014—03—19修回日期：2014—05—28·CONCLUSION：(1)OverexpressionOfVEGF，Ki一67，CD34andlowexpressionofp21suggestthattheseExpressionandsignifica

3、nceofVEGF，markersareconcernedwiththedevelopmentandprogressionofpterygium．(2)ExpressionofVEGFandCD34．Ki-67andp21inpterygiumCD34increasesalongwiththeincreaseofclinicaltypesandstages，expressionofKi-67increasesalongwiththeLj—BoWang，HaiLi，Yu—ZhouWu，YiWang，increaseofclinicaIstag

4、es．andexpressionofp21Kai—QiangWudecreasesalongwiththeimprovementofclinicaltypesorstages；theysuggestthatthesemarkersmayplayDepartmentofOphthalmology．tlleNo．1People’sHospitalofimportantroleslnthedevelopmentandrecurrenceofKunshan，Kunshan215300，JiangsuProvince，China；Department

5、pterygium．(3)ThereispositivecorrelationbetweenofPathology，theNo．1People’sHospitalofKunshan，KunshanVEGFandKi一67．VEGFandCD34aswellasnegative215300，JiangsuProvince，ChinacorrelationbetweenVEGFandp21．TheysuggestthatCorrespondenceto：Li—BoWang．DepartmentofOphthalmology，theremaybe

6、synergisticactionbetweentwofactorstheNo．IPeopIe’sHospitalofKunshan，Kunshan215300，Jiangsuduringthedevelopmentandprogressionofpterygium．Province，China．zhoujianwanglibo@163．com·KEYWORDS：pterygium；VEGF；CD34；Ki一67；Received：2014—03—19Accepted：2014—05—28p21：immunohistochemistryAb

7、stractCitation：WangLB，LiH，WuYZ，eta1．ExpressionandsignificanceofVEGF，CD34，Ki-67andp21inpterygium．Cuoji·AIM：ToinvestigatetheexpressionofVEGF，CD34，Ki一YankeZazhi(Int跏Sci)2014；14(7)：1197-120267andp21inpterygiumaswellasthecorrelationbetweentheirexpressionandclinicalpathologicaIc

8、haracteristics：exploreitsDath0genesis．摘要·METHODS：lmmunohistochemicaIS—Pstaining目的：研究VEGF、