沿心脏切线方向穿刺植入5-FU缓释粒子治疗恶性心包积液81例疗效分析.pdf

《沿心脏切线方向穿刺植入5-FU缓释粒子治疗恶性心包积液81例疗效分析.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、第50卷第12期山东大学学报(医学舨)2012年12月Vo1．50NO．12JOURNALOFSHANDONGUNIVERSITY(HEALTHSCIENCES)Dec．2Ol2文章编号：1671—7554(2012)12—0077-05DOI：10．6040／j．issn．1671-7554．2012．12．016沿心脏切线方向穿刺植入5一FU缓释粒子治疗恶性心包积液81例疗效分析李萍，梁晓红，纪永利，董亮，高洋，崔文超(胜利油田中心医院超声检查科，山东东营257034)摘要：目的探讨沿心脏切线方向穿刺植入5一Fu缓释粒子治疗恶性

2、心包积液技术的lJ盏床应用价值。方法在超声引导下对81例恶性心包积液患者沿心脏切线方向进行心包穿刺并植入5一Fu缓释粒子，治疗后每周行超声检查，4周后评价疗效，以同期心包置管引流并腔内化疗的45例患者作为对照。结果81例均一次性穿刺成功。缓释化疗粒子植入治疗后第4周超声复查，71例完全缓解，8例部分缓解，2例无效。总有效率达97．53％，高于置管引流组(77．78％)，差异有统计学意义(P<0．01)。结论沿心脏切线方向穿刺植入5一Fu缓释粒子治疗恶性心包积液操作安全，疗效好，不良反应少，是目前较为理想的治疗方案。关键词：恶性心包积

3、液；超声介入治疗；心包穿刺；5．Fu缓释粒子；心脏切线方向中图分类号：R542．12文献标志码：ATherapyeffectof5一FUpalliativeimplantedthroughpuncturingalongcardiactangentdirectionin81patientswithmalignantpericardialeffusionLIPing，LIANGXiao—hong，JIYong—li，DONGLiang，GAOYang，CUIWen—Chao(DepartmentofUltrasonography，She

4、ngliOilfieldCentralHospital，Dongying257034，Shandong，China)Abstract：ObjectiveToinvestigatetheclinicalvalueofthe5-FUsustained—releaseparticlesimplantedthroughpunctu—ringalongthecardiactangentdirectionformalignantpericardialeffusion．Methods81patientswithmalignantpericar—d

5、ialeffusionweretreatedbypericardiocentesisguidedbyultrasoundand5-FUpalliativeparticleswereimplantedintothepericardialcavity．Thepuncturingpathwasalongthecardiactangentdirection．Ultrasoundexaminationswereusedev—cryweekafterthetreatment．Theeficacywasevaluatedfourweeksafte

6、rthetreatment．The45patientstreatedbyperi—cardialcatheterdrainageandintracavitarychemotherapyattheSalYleperiodwereservedascontrols．ResultsThepunc—turingsuccessratewas100％inthe8lcases．Ultrasoundreviewsshowedthatcompleteremissionoccurredin71，partialremissionin8，andnorespo

7、nsein2casesfourweeksafterthetreatment．Thetotalremissionratewas97．53％，which'Wassignificantlyhigherthanthatinthecontrolgroup(77．78％，P<0．01)．ConclusionItisanewidealmethodtotreatmalignantpericardialeffusiontoimplant5-FUsustained·-releaseparticlesthroughpuncturingalongtheca

8、rdiactan·-gentdirectionforitshighsafetyandeficacyandlessadversereactions．Keywords：Malignantcardiaceffusion；Ultrasonic