新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注化疗治疗晚期卵巢癌的疗效观察.pdf

《新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注化疗治疗晚期卵巢癌的疗效观察.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、930中国肿瘤临床2014年第41卷第14期ChinJClinOncol2014，Vo1．41，No．14www．cjco．cn新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注化疗治疗晚期卵巢癌的疗效观察娄雪玲张占薪张喜红程艳范素珍姚丽摘要目的：探讨新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注治疗晚期卵巢癌的临床疗效。方法：分析郑州人民医院从2009年4月至2012年7月收治的60例晚期卵巢癌的患者，分为两组，研究组患者术前采取新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注辅助化疗2次(顺铂80mg)，术后给予Tc厂rP方案化疗，对照组采取常规

2、肿瘤细胞减灭术+术后TC／TP方案化疗，比较两组患者在手术时间、出血量、腹水量、术后化疗疗程、疗效、复发与死亡、生存率等数据的差异。结果：研究组患者在术中的各项疗效指标优于对照组，且有统计学显著性差异(P<0．05)，临床治疗有效率高于对照组。结论：在临床上对于晚期卵巢癌患者采取术前新辅助化疗联合肿瘤细胞减灭术术后腹腔热灌注辅助化疗，对于患者的疗效较常规的方法有较大的提高，值得在临床上进行推广。关键词新辅助化疗肿瘤细胞减灭术晚期卵巢癌热灌注化疗doi：10．3969~．issn．1000—8179．20140629Clinicalefic

3、acyofneoadjuvantchemotherapycombinedwithcytoreductivesurgeryandintraperit0nealhyperthermicchemoperfusion(IHCP)afteroperationinadvancedovariancancerXuelingLOU，ZhanxinZHANG，XihongZHANG，YanCHENG，SuzhenFAN，LiYAOCorrespondenceto：XuelingLOU；E—mail：louyixin2008@163．cornDepartmen

4、tofObstetricsandGynecology,ZhengzhouPeople’SHospital，Zhengzhou450003，ChinaAbstract0bjective：Weaimedtoinvestigatetheclinicaleficacyofneoadjuvantchemotherapycombinedwithcytoreductivesurgeryandintraperitonealhyperthermicchemoperfusion(IHCP)aftertheoperationofpatientswithadva

5、ncedovariancancer．Meth-ods：Analysisof60patientswithadvancedovariancancerwasperformedattheZhengzhouPeople’SHospitalfromApril2009toJuly2012．Thepatientsweredividedintotwogroups，namely,theresearchandcontrolgroups．Theresearchgroupwastreatedwithneoa~u—vantchemotherapycombinedwi

6、thcytoreductivesurgeryandIHCPtwice(cisplatinat80mg)，andsubsequentlNwithchemotherapy(TC／TP)．Thecontrolgroupunderwentprimarycytoreductivesurgeryandchemotherapy(TC／TP)．Wecomparedthediferencesbe—tweenthetwogroupsintermsofthefollowingparameters：operationtime，bleedingvolume，vol

7、umeofascites，andpostoperativeche—motherapy．Results：Thetreatmentsintheresearchgroupweremoreeficientthanthoseperformedonthecontrolgroupintermsofalltheintraoperativeindicators，andthediferencebetweenthetwogroupswasstatisticallysignificantfP<0．05)．Conclusion：Comparedwithconven

8、tionalmethods，theneoadjuvantchemotherapycombinedwithcytoreductivesurgeryandIHCPafteroperationwas