Ki-67、AR及FRA在三阴性乳腺癌中的表达及意义.pdf

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1、·830·田慧玲，等Ki一67、AR及FRA在三性龌疸圭麦童Ki一67、AR及FRA在三阴性乳腺癌中的表达及意义田慧玲，周风华，郑洁。，吕世军TheexpressionandsignificanceofKi一67，AR，FRAintriplenegativebreastcancerTianHuiling，ZhouFenghua，ZhengJie，LvShijunWe／fangMedicalCollege，ShandongWeifang261053，China；DepartmentofPathologyinWe扣ngMedicalCollege，ShandongWeifang26

2、1053，China．【Abstract】0bjective：ToobservetheexpressionofKi一67，androgenreceptor(AR)，folatereceptoralpha(FRA)intriplenegativebreastcancertissuesandtoinvestigatetherelationshipbetweenthethreewithTNBCprognosis．Methods：TheimmunohistochemicalstainingwasadoptedtodetecttheexpressionofKi一67，AR，FRAin80

3、casesofTNBCpatients．TherelationofKi一67，AR，FRAexpressionwiththeclinicopathologicalcharacteristicsandtheirprognosticsignificancewereanalyzed．Results：ThepositiveratesofKi一67，AR，FRAexpressionwere81．25％，25．00％，71．25％．ThepositiveexpressionrateofKi一67／FRAhadacorrelationwithhighlymphnodemetastasis，l

4、owhistologicalgradeand5yearssurvivaltimewhichwasstatisticallysignificant(P<0．05)．ThepositiveexpressionrateofARhadacorrelationwithhighhistopathologygradeand5yearssurvivaltime，whichwasstatisticallysignificant(P<0．05)．ThemoreKi一67／FRAexpression，theshortersurvivaltime．5yearssurvivaltimehadasigni

5、ficantlynegativecorelationwiththeexpressionofKi一67andFRA(r=一0．371，r=一0．498)．ThemoreARexpression，thelongersurvivaltime．5yearssurvivaltimehadapositivecorelationwithAR(r=0．465)．TheexpressionofKi一67hadasignificantlypositivecorelationwithFRA(r=0．332)，andhadanegativecorrelationwithAR(r=一0．462)．Con

6、clusion：TheTNBCpatientswiththepositiveKi一67，FRAexpressionhavepoorprognosis．TheTNBCpatientswiththepositiveARexpressionhavegoodprognosis．DetectionoftheexpressionofthesethreeantibodiesmayprovideanewindexforevaluatingtheprognosisofTNBC，andanewtargetforthetreatmentofTNBC．【Keywords】TNBC；Ki一67；AR；F

7、RA；prognosisModernOneology2014，22(O4)：0830—0833【摘要】目的：观察Ki一67、雄激素受体(androgenreceptor，AR)和一叶酸受体(folatereceptoralpha，FRA)在三阴性乳腺癌(triplenegativebreastcancer，TNBC)组织中的表达，探讨Ki一67、AR、FRA与TNBC预后的关系。方法：应用免疫组织化学法检测Ki一67、AR及FRA在80例TNBC组织中的表达，分析其与TNBC患者临床病理特征