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1、西那卡塞治疗血透患者继发性甲状旁腺功能亢进的观察【摘要】目的：观察西那卡塞治疗血透患者继发性甲状旁腺功能亢进的疗效与安全性。方法：30例血透合并继发性甲状旁腺功能亢进的患者随机分为对照组与观察组，对照组予骨化三醇治疗，观察组同时加用西那卡塞，观察比较两组治疗效果。结果：治疗后，两组患者的血清磷、iPTH较治疗前均显著下降。对照组的血钙较治疗前显著升高，观察组患者的血清磷、iPTH下降幅度显著高于对照组，差异均有统计学意义(P0.05)。结论：血透患者合并继发性甲状旁腺功能亢进，联用骨化三醇与西那卡塞治疗，
2、效果确切,安全性良好。【关键词】血液透析；西那卡塞；继发性甲状旁腺功能亢进中图分类号R692.5文献标识码A文章编号1674-6805(2016)27-0004-02ObservationofCinacalcetintheTreatmentofHemodialysisPatientswithSecondaryHyperparathyroidism/ZHANGHeng-yuan,ZHOU西那卡塞治疗血透患者继发性甲状旁腺功能亢进的观察【摘要】目的：观察西那卡塞治疗血透患者继发性甲状旁腺功能亢进的疗效与安全性
3、。方法：30例血透合并继发性甲状旁腺功能亢进的患者随机分为对照组与观察组，对照组予骨化三醇治疗，观察组同时加用西那卡塞，观察比较两组治疗效果。结果：治疗后，两组患者的血清磷、iPTH较治疗前均显著下降。对照组的血钙较治疗前显著升高，观察组患者的血清磷、iPTH下降幅度显著高于对照组，差异均有统计学意义(P0.05)。结论：血透患者合并继发性甲状旁腺功能亢进，联用骨化三醇与西那卡塞治疗，效果确切,安全性良好。【关键词】血液透析；西那卡塞；继发性甲状旁腺功能亢进中图分类号R692.5文献标识码A文章编号167
4、4-6805(2016)27-0004-02ObservationofCinacalcetintheTreatmentofHemodialysisPatientswithSecondaryHyperparathyroidism/ZHANGHeng-yuan,ZHOULing-hui,ZHANGYan-lin.//ChineseandForeignMedicalResearch,2016,14(27)：4-5[Abstract]Objective：TostudytheeffectandsafetyofCin
5、acalcetinhemodialysispatientswithsecondaryhyperparathyroidism(SHPT).Method：30hemodialysispatientswithSHPTwererandomlydividedintoobservationgroupandcontrolgroup.EachgroupwasgivenCalcitrioLbesids,theobservationgroupwasextragivenCinacalcet.Theeffectofthetwog
6、roupswereobserved.Result：Aftertreatment,ineachgroup,thelevelofphosphorandiPTHsignificantlydeclined.Incontrolgroup,thecalciumlevelincreased.ThelevelsofphosphorandiPTHintheobservationgroupwerelowerthanthoseinthecontrolgroup,thedifferenceswerestatisticallysi
7、gnificant(P0.05).Conclusion：ForhemodialysispatientswithSHPT,CinacalcetcombinedwithCalcitriolcanincreaseeffectiverateandhashighsafety.【Keywords】Hemodialysis；Cinacalcet；SecondaryhyperparathyroidismFirst-author?saddress：TheFirstAffiliatedHospitalofXiamenUniv
8、ersity,Xiamen361003,Chinadoi：10.14033/j.cnki.cfmr.2016.27.002慢性肾脏病-矿物质与骨异常(chronickidneydisease-mineralandbonedisorder,CKD-MBD)是长期透析患者常见的并发症，其中继发性甲状旁腺功能亢进(secondaryhyperparathyroidism,SHPT)的危害尤其突出，其增加骨病、心血管疾病的发生率，更增
