杞菊地黄丸对肝肾阴虚证孕妇血清IFN-γ及IL-4水平的影响.pdf

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1、中国中西医结合杂志2014年4月第34卷第4期CJITWM，April2014，Vo1．34，No．4杞菊地黄丸对肝肾阴虚证孕妇血清IFN一及IL一4水平的影响李艳芳’朱玲王淑平’顾菁。李道成’摘要目的探讨杞菊地黄丸对肝肾阴虚证孕妇证型转化的影响，以及细胞因子水平失衡与中医肝肾阴虚证间的关系。方法采用随机对照的研究方法，将163例孕12～16周，经辨证分型为肝肾阴虚证的孕妇随机分为口服杞菊地黄丸治疗组(试验组，86例)和空白对照组(对照组，77例)，比较两组孕妇治疗前后中医证型的转归以及血清细胞因子干扰素(interferon-，IFN-)和细胞

2、因子白细胞介素4(interleukin-4，IL一4)水平变化。结果(1)试验组治疗后47．7％(41／486)转化为正常证型，在随访的相同时间段内，对照组11．7％(9／77)转化为正常证型，两组比较差异有统计学意义(P

3、响细胞因子IFN一水平发挥免疫调节作用。关键词杞菊地黄丸；肝肾阴虚证；细胞因子；干扰素-；白介素-4；妊娠EfectofQUuDlhuangPIllonSerumLevelsofIFN．-yandIL一4inPregnantWomenofGan-ShenYInDeficiencySyndromeLIYan-fang，ZHULing，WANGShu—ping’，GUJing。，andLIDao—cheng’IDepartmentofObstetrics．FirstAfifiatedHospitalofGuangzhouUniversityofTra

4、ditionafChineseMedi-cine，Guangzhou(510405)，China；2DepartmentofGynecology，FirstAffiliatedHospitalofGuangzhouUniversityofditionalChineseMedicine，Guangzhou(510405)，China；3DepartmentofHealthStatis-tics，SunYat-senUniversity，Guangzhouf570080)，ChinaABSTRACTObjectiveToobservetheeffec

5、tofQijuDihuangPill(QDP)onchangesofChinesemedicalsyndrometypesinpregnantwomenofGan-Shenyindeficiencysyndrome(GSYDS)，andtoex—plorethecorrelationbetweenimbalancedcytokinelevelsandGSYDS．MethodsThiswasarandomcontrolledtrail．AtotaIof163pregnantwomenofGSYDSat12—16gestationa1weekswer

6、erandomIYalloca．tedintotheexperimentaIgroup(86cases)andthecontrolgroup(77cases)．Patientsintheexperimen-talgrouptookQDPfor2—4weeks．ChangesofChinesemedicalsyndrometypesandseruminterferon．(IFN一^y)andinterleukin-4(1L一4)levelswereobservedandcomparedbetweenthetwogroupsbeforeandafte

7、rtreatment．Results(1)Totally41patients(47．7％)intheexperimentaIgroupweretransformedtonormaIChinesemedicalsyndrometype．Inthesameperiodofthefollow—ups，9patients(11．7％)inthecontrolgroupweretransformedtonormalChinesemedicalsyndrometype，showingstatisticaldifference(P<0．05)．(2)Inthe

8、experimentalgroup，theserumIevelofIFN-^yandtheratioofIFN．~／／IL．4inthe