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时间:2020-05-24
《钙泊三醇倍他米松软膏和地塞米松霜治疗稳定期寻常性银屑病的自身对照研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、112临床皮肤科杂志2014年43卷第2期JClinDermatol,February2Q.43,.皮肤病治疗钙泊三醇倍他米松软膏和地塞米松霜治疗稳定期寻常性银屑病的自身对照研究孙彩虹,张俊,蒋国方,胡飞虎,韦珍(镇江市疾病预防控制中心,江苏镇江212000)[摘要]目的:比较钙泊三醇倍他米松软膏和地塞米松霜外用治疗稳定期寻常性银屑病患者临床疗效和安全性的差异。方法:自身左右对照临床试验研究。入组30例皮损面积<3O%休表面积的稳定期寻常性银屑病患者,均有左右侧对称皮损。随机纳入试验组或对照组。试验侧晚间外用1次钙泊三醇倍他米松软膏,对照侧晚间外用1次0.1%地塞米松霜,疗程4周。于用药后第
2、1、2、4周观察临床疗效及安全陛。结果:治疗1、2.4周后试验侧靶皮损瘙痒、红斑、浸润、鳞屑单独积分均较治疗前有所下降,4周时积分较基线时的下降比率分别为91.76%、74.26%、91.84%和87.36%,均大于对照侧(分别为69.05%、45%、41.24%和47.67%),两组差异有统计学意义(P<0.01),治疗4周时试验侧靶皮损瘙痒、红斑、浸润、鳞屑总积分较基线时的下降比率为85.98%,大于对照~U(54.77%),两组差异有统计学意义(X~47.60,P<0.01)。药物不良反应轻微,主要为与皮肤有关的轻中度反应如瘙痒、毛囊炎等,大多数都能耐受。结论:钙泊三醇倍他米松软膏治疗
3、稳定期寻常性银屑病患者起效快、疗效好,且用药方便、相对安全。f关键词]银屑病;钙泊三醇倍他米松;地塞米松;临床疗效『中图分类号]R758.63f文献标识码】A【文章编号]1ooo一4963(2014)02—0112一O3Calcipotriol/Betamethasoneointmentanddexamethasonecreaminthetreatmentofstablepsoriasisvulgaris:aself-controlled,parallelgroupstudySUNCat—hong,ZHANGJun,JIANGGuo—fang,HUFei—hu,WEIZhen(Zhenjia
4、ngCenterforDiseaseControlandPrevention,Zhenjiang212001,China)【Abstract】Objective:TostudytheclinicaleficacyandsafetyofthetopicaltherapywithCa1cipotri0l,Betamethasoneoint—mentonpatientswithstablepsoriasisvulgafis.Methods:Thirtycasesofstablepsoriasisvulgariswererandomlyenrolledinthestudvwhoselesi0nswe
5、resymmetricalandinvolvementareaswere<30%bodysurface.Aleft/rightrandomizedself—con-trolled.parallelgroupstudywasconducted.Thecoorseoftreatmentwas4weeks.Caleipotriol/Betamethasoneointmentor0.1%dexamethasonecreamwasexternallyusedeveryeveningontestgroup(side)orcontrolgroup(side),respectively.On1,2,4wee
6、kspoint,clinicaleficacyandsafetywereobserved.Results:On1,2,4weekspoint,thescoresofitching,erythema,in—filtration.scalesofthetargetlesionsweresmallerthanthoseofbaselineonbothtestandcontrolsides.Thedecreaserateoftestsidewas91.76%,74.26%,91.84%,87.36%on1,2,4weekspointrespectively,whileitwas69.05%,45%,
7、41.24%,47.67%onthecontrolside.Ontestandcontrolside,thetotalscoreofitching,erythema,infiltration,SCalesofthetargetle—sionsdeclined85.98%and54.77%respectivelyon4weekspoint.Significantdiferencewasseenbetweentw
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