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《超声早期预测重型肝炎预后的指标筛选及其价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·602·中华超声影像学杂志2014年7月第23卷第7期ChinJUltrasonogr,July2014,Vol23,No.7.临床研究.超声早期预测重型肝炎预后的指标筛选及其价值吴莉莉梁嘉仪苏中振吴涛王平郑荣琴【摘要】目的筛选超声早期预测重型肝炎预后的相关指标,并探讨其临床价值。方法回顾性分析2010年7月至2013年7月在我院诊治的269例重型肝炎患者资料,采用Cox比例风险回归模型对右肝厚度、门静脉管径等13个指标进行多因素分析,筛选预测指标,并用ROC曲线评价其临床价值。结果多因素分析显示右肝厚度、门静脉管径、附脐静脉开放及胆汁黏稠与重型肝炎患者死亡有关(P2、右肝厚度对预测重型肝炎患者死亡的贡献率最高(wald=40.479),其预测死亡的敏感性、特异性分别为93.4、82.8,(P<0.01)。结论右肝厚度、门静脉管径、附脐静脉开放以及胆汁黏稠是超声早期预测重型肝炎预后的有效指标,在治疗过程中应予以重视并密切观察。【关键词】超声检查;重型肝炎;预后;危险性评估ScreeningofearlypredictionultrasonicindexforprognosisofseverehepatitisanditsvalueevaluationWuLili,LiangJiayi,SuZhongzhen,WuTao,WangPing,ZhengR3、ongqin.DepartmentofUltrasound,theThirdAffiliatedHospitalofSunYat—senUniversity,Guangzhou510630,ChinaCorrespondingauthor:SuZhongzhen,Email:sp9313@126.corn[Abstract]0bjectiveToselectearlypredictionindexesrelatedtotheprognosisofseverehepatitisinultrasonography,andevaluateitsclinicalvalue.MethodsCli4、nica1dataof269casesofseverehepatitispatientswasanalyzedretr0spective1y.Coxproportionalhazardsregressionmodelwasadoptedtoanalyze13possiblepredictionultrasonicparametersforseverehepatitis,includingthicknessoftherighthepaticlobe,portalvein(PV)diameter,volumeofascites,etc.Afterselectedfromtheseparam5、eters,theclinicalvalueofearlypredictionfactorwasevaluatedwithROCcurve.ResultsMultivariateanalysisshowedthatthicknessoftherighthepaticlobe,portalvein(PV)diameter,openingofparaumbilicalveinandbileviscositywererelatedtothedeathofseverehepatitispatients(P<0.05).Thethicknessoftherighthepaticlobecontr6、ibutedmost(Wald=40.479),itssensitivityandspecificityforpredictionwere93.4,82.8respectively(P<0.O1).ConclusionsThicknessoftherighthepaticlobe,PVdiameter,openingparaumbiliealveinandbileviscosityareearlypredictionfactorsforseverehepatitis,needtobemonitoredintreatment,especiallyforthicknessoftherigh7、thepaticlobe.[Keywords]Ultrasonography;Severehepatitis;Prognosis;Riskassessment重型肝炎是以大量肝细胞坏死为主要病理特点的资料与方法一种严重肝疾病,可引起肝衰竭甚至危及生命,是肝病患者死亡的主要原因之一[1]。超声检查能准确反映肝一、一般资料大小及血流动力学变化,有助于重型肝炎的早期诊断,回顾性分析2010年7月至2013年7月在我院诊对治疗起到指导作用],但有关超声
2、右肝厚度对预测重型肝炎患者死亡的贡献率最高(wald=40.479),其预测死亡的敏感性、特异性分别为93.4、82.8,(P<0.01)。结论右肝厚度、门静脉管径、附脐静脉开放以及胆汁黏稠是超声早期预测重型肝炎预后的有效指标,在治疗过程中应予以重视并密切观察。【关键词】超声检查;重型肝炎;预后;危险性评估ScreeningofearlypredictionultrasonicindexforprognosisofseverehepatitisanditsvalueevaluationWuLili,LiangJiayi,SuZhongzhen,WuTao,WangPing,ZhengR
3、ongqin.DepartmentofUltrasound,theThirdAffiliatedHospitalofSunYat—senUniversity,Guangzhou510630,ChinaCorrespondingauthor:SuZhongzhen,Email:sp9313@126.corn[Abstract]0bjectiveToselectearlypredictionindexesrelatedtotheprognosisofseverehepatitisinultrasonography,andevaluateitsclinicalvalue.MethodsCli
4、nica1dataof269casesofseverehepatitispatientswasanalyzedretr0spective1y.Coxproportionalhazardsregressionmodelwasadoptedtoanalyze13possiblepredictionultrasonicparametersforseverehepatitis,includingthicknessoftherighthepaticlobe,portalvein(PV)diameter,volumeofascites,etc.Afterselectedfromtheseparam
5、eters,theclinicalvalueofearlypredictionfactorwasevaluatedwithROCcurve.ResultsMultivariateanalysisshowedthatthicknessoftherighthepaticlobe,portalvein(PV)diameter,openingofparaumbilicalveinandbileviscositywererelatedtothedeathofseverehepatitispatients(P<0.05).Thethicknessoftherighthepaticlobecontr
6、ibutedmost(Wald=40.479),itssensitivityandspecificityforpredictionwere93.4,82.8respectively(P<0.O1).ConclusionsThicknessoftherighthepaticlobe,PVdiameter,openingparaumbiliealveinandbileviscosityareearlypredictionfactorsforseverehepatitis,needtobemonitoredintreatment,especiallyforthicknessoftherigh
7、thepaticlobe.[Keywords]Ultrasonography;Severehepatitis;Prognosis;Riskassessment重型肝炎是以大量肝细胞坏死为主要病理特点的资料与方法一种严重肝疾病,可引起肝衰竭甚至危及生命,是肝病患者死亡的主要原因之一[1]。超声检查能准确反映肝一、一般资料大小及血流动力学变化,有助于重型肝炎的早期诊断,回顾性分析2010年7月至2013年7月在我院诊对治疗起到指导作用],但有关超声
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