超声引导肝恶性肿瘤射频消融术与手术切除对细胞免疫影响的对比研究.pdf

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1、·376·临床超声医学杂志2014年6月第16卷第6期JClinUhrasoundinMed，June2014．Vo1．16．No．6·Il台床研究-超声引导肝恶性肿瘤射频消融术与手术切除对细胞免疫影响的对比研究闫景彬闫秀梅陈斌孙宏伟摘要目的探讨超声引导下射频消融术与手术切除术对肝癌患者外周血T淋巴细胞亚群的影响。方法应用流式细胞仪检测，30例以射频消融为治疗方式和30例以手术切除为治疗方式的原发性肝癌患者的术前、术后T淋巴细胞亚群的变化。结果射频组术后10d和20d外周血中CD3、cD4、CD4VCD8~TJ~平均明显高于术前水平，CD8+明显低于术前

2、，差异均有统计学意义(均P

3、arisonofcellularimmunityinhepaticmalignanttumorstreatedbyultrasound-guidedradiofrequencyablationandsurgicalresectionYANJingbin，YANXiumei，CHENBin，SUNHongweiDepartmentofUltrasound，WenzhouHospitalofIntegratedChineseandWestrenMedicine，Wenzhou325000，ChinaABSTRACTObjectiveTostudytheinf

4、luenceofultrasound-guidedradio~equencyablationandsurgicalresectionofprimaryhepatocellularcarcinomaonTlymphocytesubsetsintheperipheralblood．MethodsTlymphocytesintheperipheralbloodofpatientsinthetwogroups(30patientstreatedbyradio~equencyablationand30treatedbysurgicalresection)werea

5、ssayedbyflowcytometry．Results10dand20dafterthetreatment，thelevelsofCD3andCD4CFlymphocytesoftheradiofrequencyablationgroupwereincreased，thelevelofCD8Tlymphocytewasdecreased，CD4+／CD8ratiowasincreased，andthedifferencewassignificant(P

6、fCD3andCD4Tlymphocytesofthesurgicalresectiongroupweredecreased，thelevelofCD8q"lymphocytewasincreased，CD4VCD8ratiowasdecreased(P

7、up，andthelevelofCD8lymphocytewaslower，thedifferencewassignificant(P<0．05)．ConclusionRadio~equencyablationimprovestheimmunesuppressionandenhancesthecellularimmunefunction，whilesurgicalresectiondecreasesthecellularimmunefunction．Radio~equeneyablationisbetterthansurgicalresectioninp

8、rotectingandimprovingthecellularimmunefu