结核性和恶性胸膜炎患者VEGF的水平及意义.pdf

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1、国际呼吸杂志2014年6月第34卷第l2期IntJRespir，June2014，Vo1．34，No．12·889·．论著．结核性和恶性胸膜炎患者VEGF的水平及意义梅早仙吴琦叶静张学丽孙海柏韩骏锋【摘要】目的通过检测结核性胸膜炎及恶性胸膜炎患者血清和胸水中血管内皮生长因子(VEGF)含量，分析VEGF在两组患者血清、胸水中的差异，探讨VEGF在二者中的意义和诊断价值。方法对确诊结核性胸膜炎和恶性胸膜炎各3O例的患者在同一日留取胸水标本1Oml及静脉血5ml，采用双抗体夹心酶联免疫吸附试验检测患者胸水及血清中VEGF水平，分析其

2、差异及相关性。结果结核组血清和胸水VEGF检测值分别为(45．33±18．a3)ng／L、(62．73士24．65)ng／L；恶性组血清和胸水VEGF检测值分别为(66．00±29．83)ng／L、(95．54-+-42．11)ng／L；恶性组血清及胸水中VEGF含量均高于结核组(t值分别为3．9、5．2，P值均d0．05)。VEGF在两组的血清和胸水中均呈正相关性(r值分别为0．53、0．38，P值均d0．05)。结论在结核性胸膜炎及恶性胸膜炎患者血清、胸水中VEGF水平有差异，恶性高于结核性；两组患者胸水中VEGF含量均高于

3、血清，胸水VEGF含量随着血清VEGF含量增高而增高。检测胸腔积液患者血清和胸水中VEGF含量对结核性胸膜炎和恶性胸膜炎的诊断和鉴别诊断有一定的价值。【关键词】血管内皮生长因子；胸腔积液；结核；恶性肿瘤VEGFlevelandsignificanceoftuberculouspleurisyandmalignantpleurisyMe~Zaoxian，WuQi，YeJing，ZhangXueli，SunHaibai，HanJunfeng．DepartmentofTuberculosis，TianjinHa~heHospital，

4、Tianjin300350，ChinaCorrespondingauthor：Qi，Email：wqw572004@yahoo．corn．cn[Abstract]0bjectiveToanalysethedifferenceandexplorethediagnosissignificanceofvascularendothelialgrowthfactor(VEGF)inserumandpleuralfluidofpatientswithtuberculouspleurisyandmalignantpleurisybymeasu

5、ringtheconcentrationsofVEGFinserumandpleuralfluid．Methods10mlpleura1fluidand5mlbloodasspecimenfrompatientswithtuberculouspleurisyandmalignantpleurisy(each30cases)werecollectedonthesameday．TheVEGFconcentrationsofserumandpleuralfluidweremeasuredbytheenzyme—linkedimmuno

6、sorbentassay．Thedifferenceandcorrelationwereanalysed．ResultsIntuberculouspleurisygroup，thevEGFlevelswere(45．33±18．33)ng／Linserumand(62．73±24．65)ng／Linpleuralfluid．Inmalignantpleurisygroup，theVEGFlevelswere(66．O0±29．83)ng／Linserumand(95．54士42．11)ng／Linpleuralfluid．The

7、VEGFlevelsofserumandpleuralfluidinmalignantpleurisygroupwerehigherthanthoseintuberculouspleurisygroup(t一3．9，5．2，respectively，allP<0．05)．VEGFlevelsinserumandpleuralfluidinthetwogroupsshowedpositivecorrelation(r一0．53，0．38，respectively，allP<0，05)．ConclusionsThelevelsofV

8、EGFinserumandpleuralfluidaredifferentbetweenpatientswithtuberculouspleurisyandpatientswithmalignantpleurisy．Theserumandpleuralfluid