密集型银质针疗法联合关节内臭氧注射治疗膝骨关节炎中远期疗效观察.pdf

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1、·494·中国疼痛医学杂志ChineseJoumalofPainMedicine2014．20f7doi：10．39698．issn．1006·9852．2014．1．000密集型银质针疗法联合关节内臭氧注射治疗膝骨关节炎中远期疗效观察凌地洋王哲银卢振和陈金生黄乔东(暨南大学第二临床医学院深圳市人民医院疼痛科，深圳518020广州医科大学第二附属医院疼痛科，广州510260)摘要目的：观察密集型银质针疗法联合关节内臭氧注射治疗膝骨关节炎的中远期疗效和安全性方法：120例符合纳入标准的膝骨关节炎患者按随机数字表法均分为两组，观察组关节内分次注射35~tgCmL的臭氧共6O～8

2、0ml，每周1次，共5次，同时给予膝周软组织密集型银质针治疗2～3次；对照组关节内注射透明质酸钠，每周1次，共5次。比较两组治疗前后患者的视觉模拟评分(visualanaloguescore，VAS)、关节活动度(raneofmotion，ROM)，Lysholm膝关节功能评分和治疗后6个月的临床疗效。结果：末次治疗后6个月VAS评分、ROM和Lysholm膝关节功能评分均较治疗前明显改善(P<0．05)；观察组VAS评分明显低于对照组，ROM、Lysholm膝关节功能评分明显高于对照组(P<0．05)；观察组总优良率与总有效率均明显高于对照组(38．9，P<0．01；=8

3、．91，P<0．05)。结论：密集型银质针疗法联合关节内臭氧注射治疗膝骨关节炎中远期疗效优于单纯关节内注射透明质酸钠治疗。关键词银质针疗法；臭氧；注射；关节内；膝关节；骨关节炎MEDIUM-LoNGTERMEFFICACYoFDENSESILVERNEEDLErI’HERAPYC0MBINEDWITHINTRA．ARTICULARINJECTIoNoFoZoNEINPATIENTSWITHKNEEoSTEoARTHRITISLINGDi—Yang，WANGZhe—Yin，LUZhen-He，CHENJin—Sheng，HUANGQiao—Dong(DepartmentofP

4、ainMedicine，theSecondClinicalMedicalCollegeofJinanUniversity,ShenzhenPeople’SHospital，Shenzhen518020；DepartmentofPainMedicine，theSecondAffiliatedHospitalofGuangzhouMedicalCollege，Guangzhou510260)Abstract0bjective：Toinvestigatethemedium-longtermeficacyandsafetyofdensesilverneedletherapycomb

5、inedwithintra-articularinjectionofozoneinpatientswithkneeosteoarthritis．Methods：Totally120patientswiththeinclusioncriteriaofkneeosteoarthritiswererecruifedandrandomized．60Patientsintheobservationgroupreceivedasequenceoftreatmentofintra—articularinjectionof60——80mlozonewith35~tg／mL，onceawee

6、kforfiveweeks，followedbydensesilverneedletherapy2～3timesonsofttissuearoundtheknee．Theother60patientsinthecontrolgroupunderwentintra—articularinjectionofsodiumhyaluronate，onceaweekforfiveweeks．Thevisualanaloguescale(VAS)，rangeofmotion(ROM)．theLysholmkneefunctionalscorewereassessedbeforeanda

7、ftertreatment．Results：TheVASscore，ROM，andtheLysholmkneefunctionalscoreinbothgroupwereimprovedsignificantlyat6monthsafterthelasttreatment(P<0．05)．ThescoresofVAS，ROM，andtheLysholmkneefunctionintheobservationgroupimprovedmorecomparedwiththecontrolgrouprP<0．05)．Th