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时间:2020-05-24
《螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华临床免疫和变态反应杂志CHINESEJOURNALOFALLERGY&CLINICALIMMUNOLOGY·论著·螨制剂舌下免疫治疗对单一和多重致敏变应性鼻炎的疗效评估许晨霞,张妙莲,邹泽红,何颖,伍秋容,赖荷,陶爱林#(F'kH科大学附属第二医院广东省过敏反应与免疫重点实验室,呼吸疾病国家重点实验室变态反应研究室,广州510260)摘要:目的观察单一和多重变应性鼻炎患者舌下脱敏的疗效异同并分析原因。方法回顾性分析舌下脱敏治疗1年以上单一和多重变应性鼻炎患者终止治疗1年后的疗效,并对粉尘螨变应原组分与其他点刺变应原作
2、同源进化树分析。结果纳入患者50例,舌下免疫治疗显效22例,有效15例,无效13例,总有效率为74%。50例患者中30例(60%)为多重变态反应患者,阳性率最高的前3种变应原依次为蟑螂(83%)、冬季花粉(70%)和蚕丝(63%)。用有序多分类资料比较的秩和检验分析舌下脱敏治疗1年以上单一尘螨过敏患者与多重变态反应患者的疗效,两组总体分布相同。结论使用舌下含服粉尘螨滴剂治疗变应性鼻炎,多重与单一尘螨变态反应患者治疗效果相当。粉尘螨滴剂亦可用于多重变态反应患者常规治疗。关键词:尘螨;变应性鼻炎;舌下脱敏治疗;疗效分析中图分
3、类号:R593.1,R765.2文献标志码:A文章编号:1673—8705(2014)02-0095-06DOI:10.3969/j.issn.1673—8705.2014.02.002ClinicalEvaluationofEficacyofSublingualImmunotherapywithDermatophagoidesfarinaeExtractamongMonosensitizedandPolysensitizedPatientswithAllergicRhinitisxuChen—xia,ZHANGMiao
4、—lian,ZOUZe—hong,HEYing,WUQiu—rong,LAIHe,TAOAi.1in(GuangdongProvinceKeyLaboratoryofAllergy&Immunology/AllergyResearchBranchoftheStateKeyLaboratoryofRespiratoryDiseaseSecondAfiliatedHospitalofGuangzhouMedicalUniversity,Guangzhou510260,China)objectiveToinvestigatet
5、hepotentialdifferenceofeficacyofsublingualimmunotherapybetweenmonosensitizedandpolysensitizedallergicrhinitispatients.MethodsClinicaleficacyofsublingualimmunotherapywasevaluatedamongmonosensitizedpatientsandpolysensitizedpatientswhoweretreatedwithsublingualimmuno
6、therapymorethan1year.20casesofmonosensitizedpatientswhoweresensitizedtohousedustmiteand30casesofpolysensitizedpatientswhoweresensitizedtohousedustmitesandotherallergenswereinvolvedinthisstudy.Thephylogenetictreeoftheallergeniccomponentsofhousedustmiteandotheralle
7、rgensusedinskinpricktestwasconstructed.ResultsAmong50easesinvolvedinthisstudy,evidenteffectshownin22eases,moderateeffectin15cases,andinefficacyin13cases.Thetotaleffectiveratewas74%.Ofall50patientswithallergicrhinitis,30eases(60%)werepolysensitizedpatients.Thetopt
8、hreekindsofallergenswiththehighestpositiveratewerecockroach(83%),winterpollen(70%),andsilk(63%)respectively.Therewasnosignificantdifferencestatisticallybetween
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