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1、介入性热化疗栓塞治疗结肠癌肝转移(word版)作者：赵年，夏进东*,李春华，李云珍，李德秀作者单位：(员耶日医学院附属东风医院影像部，湖北十堰442008)【摘要】目的：评价介入性热化疗栓塞治疗结肠癌肝转移的临床效果。方法：63例结肠癌肝转移患者随机分为两组，热化疗组30例，将5Fu、丝裂霉素及顺伯用热疗机加热至65°C后经导管缓慢注入肝动脉，再用超液化碘油栓塞肿瘤供血动脉。常温组33例，经导管将与热化疗组相同化疗药常温灌注后用超液化碘油栓塞肿瘤供血动脉。观察体温、肝功能变化。每月复查癌胚抗原(CEA)及肝脏CT,观察肿瘤内碘油沉积及病灶大小、数目，统计患者生存率
2、。结果：治疗后热化疗组生存率较常温组有显著性增加(P<0.01),其6、12、18、24月生存率分别为100%、93%、73%、60%;其肿瘤数目及大小较常温组明显减少和缩小(P<0.01);两组之间碘油沉积、体温、肝功能变化无差异(P>0.05)o结论：介入性热化疗栓塞治疗结肠癌肝转移能显著提高疗效，延长生存期。【关键词】结肠癌;肝;转移;介入性;热疗InterventionalThermochemoembolotherapyforHepaticMetastasisofColonCarcinomaZHAONian,XIAJindong*,LIC
3、hunhuazLIYunzhen,LIDexiu(DepartmentofRadiology,DongfengHospital,YunyangMedicalCollege,Shiyan,Hubei442008,China)AbstractObjectiveToevaluatetheclinicaleffectsofinterventionalthermochemoembolotherapyonpatientswithhepaticmetastasisofcoloncarcinoma.MethodsSixtythreepatientssufferingfromhep
4、aticmetastasisofcoloncarcinomawererandomlydividedintothermochemotherpygroup(30cases)androutinechemotherapygroup(33cases).Inthermochemotherpygroup,5Fu,mitomycinandcisplatinwhichwereheatedto65°Cwereslowlyinjectedintohepaticarterythroughcatheter,andthenembolizedthefeedingarteryofcarcinom
5、abylipiodol.lnroutinechemotherapygroup,thesamedrugswithoutheatingwereusedwiththesamewayasthethermochemotherpygroup.Bodytemperatureandhepaticfunctionwereobserved.CEAandliverCTwereperformedmonthly’thesituationoflipiodoldepositionaswellasthesizeandnumberoftumorwasobservedandthesurvivalra
6、tewasalsoanalyzedeverymonth.ResultsComparedwithroutinechemotherapygroup,thesurvivalratewassignificantlyincreasedinthermochemotherpygroup,andthesurvivalrateof6,12,18,24monthswas100%,93%,73%,60%/espectively.Thesizeoftumorwassmallerandthenumberwaslessinthermochemotherpygroupthanroutinech
7、emotherapygroupsignificantly(P<0.01).However,therewasnosignificantdifferencebetweentwogroupsinlipiodoldeposition,temperature,hepaticfunctionandcomplication(P>0.05).ConclusionInterventionalthermochemoembolotherapycaneffectivelyenhanceefficacyofhepaticmetastasisofcoloncarcinoma,an
8、dprol
