黄芩苷联合干扰素α治疗慢性乙型肝炎疗效及对细胞免疫的影响.pdf

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1、中国现代药物应用2014年1月第8卷第2期ChinJModDrugAppl，Jan2014。Vo1．8．No．2·3·黄芩苷联合干扰素治疗慢性乙型肝炎疗效及对细胞免疫的影响李新成王宏伟申保生宋新文【摘要】目的研究黄芩苷联合干扰素ot治疗慢性乙型肝炎临床疗效及对肝纤维化指标和细胞免疫的影响。方法92例慢性乙型肝炎患者随机分为对照组(46例)和治疗组(5O例)，对照组给予干扰素a-2b治疗，治疗组用黄芩苷联合干扰素a-2b。治疗六个月后观察肝功能、肝纤维化指标、HBeAg及HBV-DNA阴转、CD4+、cD以及NK细胞亚群变化情况。结果两组患者肝功能、肝纤维化指标

2、与治疗前相比均明显改善(P<0．O1)，但以治疗组改善更为显著(P<0．O1)；与对照组相比，治疗组患者HBeAg及HBV-DNA阴转率显著高于对照组(P<0．05，P<0．01)；与对照组相比，治疗后治疗组CD4T及NK细胞比例显著高于对照组，而CDs+T细胞比例显著低于对照组，CD4+／CD~+比值显著高于对照组(P<0．01)。结论黄芩苷和干扰素联用在抗炎、抗肝纤维化、促进HBeAg和HBV．DNA转阴及改善细胞免疫状态方面具有协同作用。【关键词】黄芩苷；干扰素a-2b；慢性乙型肝炎；肝纤维化；细胞免疫Baiealincombinedwithinterf

3、eronfortreatingpatientswithchronichepatitisBanditseffectsoncellu-larimmunityXin—cheng，WANGHong—wei，SHENBao—sheng，eta1．DepartmentofInfectionDiseases，HuixianPeople’sHospital，Huixian453600，China【Abstract】ObjectiveTostudytheclinicaleficacyofbaicalincombinedwithinterferono【fortreatingpat

4、ientswitllchronichepatitisB(CHB)anditsefectsonindicatorsofhepaticfibrosisandcellularimmunity．Methods92patientst}lCHBwererandomlydividedintothecontrolgroupandthetreatmentgroup．Thecon—trolgroupreceivedthetreatmentofinterferonalfa-2b(n=46)，whilethetreatmentgroupreceivedthecombina-tiont

5、herapyofinterferonalfa-2bandbaiealin(n=50)．Hepaticfunctions，indicatorsofhepaticfibrosis，statusofcellularimmunity，HBeAgandHBV-DNAweremeasuredbeforeandaftertreatment．ResultsHepaticfunc-tionsandindicatorsofhepaticfibrosiswereimprovedsignificantlyafterthetreatmentforallthepatients(P<0．0

6、1，respectively)，butmoresignificantlyinthetreatmentgroup(P<0．01，respectively)．Thenegativetrans—formedratesofHBeAgandHBV—DNAintreatmentgroupweresignificanthigherthanthoseinthecontrolgroup(P<0．05，P<0．01，respectively)．Comparedwiththecontrolgroup，thepmpo~ionofCD4+andNKin-creasedsignifica

7、ntly，proportionofCDs+decreasedandtheratioofCD4+／CDs+increasedsignificantlyaftertreat-mentinthetreatmentgroup(P<0．O1)．ConclusionThecombinationofbaiealinandinterferonalfa-2bcouldimprovethecellularimmunityandtheseranegativetransformedrate，protectliverceilsfrominflammationandprohibitive

8、liverfibrosis．【Keyw