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《经动脉化疗栓塞联合索拉非尼治疗肝癌的肝动脉血流动力学 DSA 图像.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、584-——介入放射学杂志2014年7月第23卷第7期JInterventRadiol2014,Vo1.23,No.7.——·肿瘤介人Tumorintervention·经动脉化疗栓塞联合索拉非尼治疗肝癌的肝动脉血流动力学DSA图像陈骏,席玮,武贝,余辉,吴建达,陆逸,陈世唏【摘要】目的探讨经动脉化疗栓塞(TACE)联合索拉非尼治疗肝癌后短期内的肝动脉DSA血流动力学表现。方法回顾性分析30例TACE治疗肝癌病例,其中治疗组13例,对照组17例。治疗组除接受TACE治疗外,还在治疗前1周、或治疗后2周内开始口服索拉非尼400mg每日2次。对照组只给予T
2、ACE治疗。分析患者第1次和3个月后TACE治疗的DSA图像。用Photoshop软件在动态系列DSA图像上测量肿瘤的染色灰度,并绘制肿瘤染色的时间一密度曲线。比较两组患者肿瘤染色的峰值强度(Pv),达峰值时间(TP)和曲线上升支斜率(SU)。结果Photoshop软件可以测量DSA图像中肿瘤组织的染色灰度。治疗组治疗后的染色PV小于治疗前(分别为38.0±14.6和46.7±18.4,P=0.040)、也小于对照组治疗后的染色PV(分别为38.0±14.6和54.4±19.8,P=0.叭1)。两组之间以及每组治疗前后的rrP和SU差异无统计学意义。结
3、论TACE联合索拉非尼治疗肝癌后短期内的肝动脉DSA肿瘤染色峰值下降。【关键词】肝肿瘤;放射学,介入性;血流动力学中图分类号:R735.7文献标志码:A文章编号:1008.794X(2014)一07—058404HepaticarterialhemodynamicsobtainedfromDSAimagesinpatientswithhepatocellularcarcinomatreatedbyTACEplussorafenib:apreliminarystudyCHENJun,XIWei,Bei,YUHui,m—da,LUYi,CHENShi—xi
4、.InterventionDivision,DepartmentofRadiology,JiangsuCancerHospital&CancerHospitalofNanjingMedicalUniversity,Nanjing,~angsuProvince210009,ChinaCorrespondingauthor:CHENShi—,E—maiZ:chenshixi2DD7@126.com【Abstract】ObjectiveToinvestigateDSA-estimatedhepaticarterialhemodynamicsofhepatoc
5、ellularcarcinoma(HCC)determinedshortlyaftertranscathetera~efialchemoembolization(TACE)plussorafenibtreatment.MethodsTheclinicaldataofthirtyHCCpatientstreatedwithTACEwereretrospectivelyanalyzed.Thepatientsweredividedintostudygroup(n=13)andcontrolgroup(n=17).Patientsinthestudygrou
6、preceivedadditionaloraladministrationof400mgsorafenibtwiceadayoneweekbeforeortwoweeksafterTACEprocedure,whilepatientsinthecontrolgroupreceivedTACEonly.TheinitialDSAimagesaswellas血eimagesohtainedatthreemonthsafterTACEwereanalyzed.WiththehelpofPhotoshopsoftware,thegreygradientofth
7、etumorstainingwasmeasuredontheseriesdynamicDSAimages,basedonwhichthetime—densitycurveofthetumorwasdrawn.Thepeakdensityvalue(PV),thetimetoreachthepeak(TP)andtheslopeoftheupslope(SU)weredetermined,andtheresultswerecomparedbetweenthetwogroups.ResultsPhotoshopsoftwarewasusedtomeasur
8、ethegreydensityvaluesofthetumorstainingonDSAima
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