髓母细胞瘤的MRI和MRS特征分析-论文.pdf

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1、神经影像学NEUROLOGlCALIMAGlNG222髓母细胞瘤的MRI和MRS特征分析李劲，梁宗辉李克褚梅花赵华丽【摘要】目的：通过分析髓母细胞瘤的MRI表现，提高对髓母细胞瘤的认识。方法：回顾性分析33例经手术病理证实的髓母细胞瘤，对肿瘤发生部位、MRI信号、增强后强化、囊变、出血以及MRS等表现进行分析。结果：33例髓母细胞瘤中22例位于第四脑室小脑蚓部区，9例位于半球；其中T1wI呈低信号或略低信号29例，等低混杂信号3例；T2WI呈略高信号或不均匀略高信号24例，高信号5例；DWI高信号32例；增强扫描轻度或中度云絮状

2、强化17例，明显强化l1例；病灶内微囊变20例，中囊变6例；19例见瘤周囊变。以1O岁或20岁为界分组，分析发生于中线和小脑半球无统计学差异(P>0．05)。5例行1H—MRS检查，实性部分Cho峰明显升高，NAA峰降低，Cho／Cr~)．Cho／NAA明显升高，Lac峰轻度升高。结论：髓母细胞瘤在MRI具有一定的影像学特征，结合MR多功能成像技术，有助于提高诊断正确率。【关键词】髓母细胞瘤；磁共振成像；磁共振波谱成像中图分类号：R445．2；R447；R604文献标志码：A文章编号：10065741(2014)．03．0222

3、—05AnalysisonMRIandMRSFeaturesofMedulloblastomaLIJin。。，LIANGZong～hui，LIKe，CHUMei—hua，ZHAOHua—li【Abstract】Purpose：ToinvestigatetheMRfindingsandMRspectroscopyfeatureofmedulloblastoma．Methods：Thirty—threecasesofmedulloblastomaconfirmedbyhistopatho1ogywereanalyzedretrOsp

4、ectivelyonlocation，signalintensity，enhancementpattern，cysts，bleedandMRspectroscopy．Results：Of33medulloblastomas，22locatedinthefourventriclecerebellarvermis，9locatedinthehemisphere．Twenty-ninecaseswereshownwithhypo—intensesignal，and3caseswereshownwithhypo-intenseoriso

5、-intenseon．Twenty-fourcaseswereshownwithslightlyhyper-intenseorheterogeneoushyper-intensesigna1．and5caseswereshownwithhyper-intensesignalonT2WI．Thirty—twocaseswerewithhyper-intensesignalonDWI．Thesolidcomponentswithsubtleormediumenhancementin17cases，andmarkedenhanceme

6、ntin11．Twentycaseswerewithintra-lesionmicro-cysts，and6withmid—cysts．Peri·lesioncystswereshownin19cases．Therewasnosignificantdifferencebetweentheoccurrenceoftumor1ocatedinthemidlineandinthecerebelluminpatientsyoungerthan10or20andolderthan10or20(尸>O．05)．Spectralmapsof5

7、casesshowedhighcholineandLacpeak，lowNAApeak，andasignificantlyhighCho／CrandCho／NAAratio．Conclusion：MedulloblastomahassomecharacteristicfeaturesofMRIandMRS，fromwhichpreoperativediagnosiswillbenefit．【Keywords】Medulloblastoma；Magneticresonanceimaging；Magneticresonancespe

8、ctroscopy髓母细胞瘤(medulloblastoma)是颅后窝较常细胞瘤进行MRI表现进行分析，在发现和以往文献报见的恶性肿瘤，占儿童中枢神经系统肿瘤的1／4左右。道部分一致的常见MRI特征的同时，提出一些相对少本文结合国内外文献，对本院33例经病理证实