心脏负荷实验中超声造影对心肌微血管的损伤影响.pdf

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1、·76·临床超声医学杂志2015年2月第17卷第2期JClinUltrasoundinMed，Feburary2015，Vo1．17，No．2·实验研究·心脏负荷实验中超声造影对心肌微血管的损伤影响魏立亚张雁王宏婵摘要目的探讨心脏负荷实验中超声造影对心肌微血管的损伤效应。方法20只大白兔随机均分为4组：单纯超声触发组(A组)、静息超声触发组(B组)、负荷超声触发组0．5ml／kg(C组)和O．05ml／kg(D组)。心电监测有无室性期前收缩，依文思蓝(EB)视觉评分分析血管通透性，光镜观察心肌血管和细胞损伤情况。结果B组、C

2、组、D组EB含量均高于A组(P

3、码】AImpactofcontrastechocardiographyonmyocardialmicrovascularinjuryduringcardiacstresstestWeiLiya，ZhangYan，WangHongchanDepartmentofUhrasound，ShenzhenHospitalofPekingUniversity，Shenzhen518000，ChinaABSTRACTObjectiveToinvestigatetheimpactofcontrastechoeardiographyonmyo

4、cardialmierovascularinjuryduringcardiacstresstest．MethodsTwentyrabbitswererandomlydividedinto4groups：simpleultrasound-triggeredgroup(groupA)，restingultrasound-triggeredgroup(groupB)，stressultrasound-triggeredgroupwithmicrobubblesatthedoseof0．5ml／kg(groupC)and0．05ml

5、／kg(groupD)．ECGwas印pliedtomonitorprematureventrieularcontraction．Evansblue(EB)visualscoreswereappliedtoanalyzethevascularpermeability．Injuryinbloodvesselsandmyocardialcellswereobservedunderthemicroscopy．ResultsIngroupB，CandD，EBextractioncontentwashigherthanthatingr

6、oupA(P<0．05)．HemorrhagewasseenontheSurfaceofmyoeardiumingroupCandD，EBwasobservedingroupB．ThevisualscoresingroupB，CandDwerehigherthanthoseingroupA(P<0．05)．ThevisualscoresingroupCandDwerealsohigherthanthoseingroupB(P<0．05)．Prematureventrieularcontractionwasfoundingro

7、upB，CandD，thedifferencesbetweengroupswerenotstatisticallysignificant．AlotofredbloodcellswereobservedintheintercellularspaceingroupCandD，themyocardialcellswereinjuredobviously。whilesporadicredbloodcellswereobservedintheinterceHularspaceingroupB．ConclusionDuringcardi

8、acstresstest，thebiologicaleffectsofcontrastechocardiographywouldcauseobviousmierovaseulardamage．KEYWORDSUltrasonography；Contrastagent；Cardiacstre