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《系统性红斑狼疮患者自身抗体联合检测的诊断意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、王霞等系统性红斑狼疮患者自身抗体联合检测的诊断意义第11doi:10.3969/j.issn.1000—484X.2011.11.016·实用临床免疫学·系统性红斑狼疮患者自身抗体联合检测的诊断意义李王霞谢文①宁勇②沈钢(武汉血液中心,武汉430030)中国图书分类号R457.11文献标识码A文章编号1000·484X(2011)11-1027-03[摘要]目的:通过检测抗sm抗体、抗dsDNA抗体、抗核糖体P蛋白抗体(anti—raNP),探讨它们在系统性红斑狼疮(SLE)中的临床意义。方法:采用免疫荧光法对93例SLE患
2、者及120例其他自身免疫病患者(简称非SLE组)进行抗sm抗体、抗dsDNA抗体、抗核糖体P蛋白抗体检测;数据采用统计软件SPSS13.0进行分析,组问率比较用R×C表检验。结果:三种抗体阳性率无论是单项检测还是联合检测都明显高于非SLE组(P3、E的诊断及鉴别诊断。[关键词]抗Sm;抗dsDNA;抗核糖体P蛋白抗体;系统性红斑狼疮ThediagnosissignificanceofcombineddetectionofautoantibodiesinSystematicLupusErthematosus,L/Wang—Xia,XIEWen,NING,SHEN.BloodCenterofWuhan,Wuhan430030,China[AbstractJObjective:Toevaluatethesignificanceofanti—Sm,anti—doubles~a4、ndeddDNA(anti—dsDNA)andanti—ribosomalPproteinantibodies(antiI—rRNP)onthediagnosisinpatientswithsystemiclupuserythematosus(SLE).Methods:In93patientswithSLE,120patientsofotherautoimmunedisease(Non-SLE),anti—Sm,anti—dsDNAandanti-rRNPweretestedbyimmunofluoreseenee.Stat5、isticalanalysisWasmadeusingSPSS13.0andthediferencesamonggroupswerecomparedusingZtest.Results:Theresultsshowedthatthepositiveratesofanti—Sm,anti—dsDNAandANTI—RRNPinSLEpatientsweremuchhigherthanthoseinpatientswithNon-SLEgroups(P<0.01)eitherindividualde—tectionorcombi6、neddetection.OneorseveralantibodyCanbetestedinSLEpatientswitIlnegativeantibodyserum.CombineddetectionofthethreeautoantibodiesimprovedthespecificityandpoteivepredictivevalueofSLEdiagnosisexceptanti—dsDNA+anti—rRNP,butsensitivityandnegadvepredictivevaluewerelowerthan7、individualdetection.Conclusion:Anti一n,anti.dsDNAandanti—rRNPhaveitselfsi鲥ficanceindi—agnosis.Thecombineddeterminationmayhaveimportantsignificanceindiagnosis,diferentialdiagnosisinpatientswithSLE.1KeywordsJAnti—Sm;Anti—doublestrandedDNA;An【i—ribosomalPprotein;Antibo8、diessystematiclupuse~thematosns自身免疫性疾病是自身免疫功能异常紊乱的性率较低。近几年,有学者研究表明:anti.rRNP对一类疾病,通常在免疫细胞、自身抗体的参与下,导SLE的诊断有高度的特异性。本研究通过对系统性致组织器官损伤及功能障碍。系统性红斑狼疮是常
3、E的诊断及鉴别诊断。[关键词]抗Sm;抗dsDNA;抗核糖体P蛋白抗体;系统性红斑狼疮ThediagnosissignificanceofcombineddetectionofautoantibodiesinSystematicLupusErthematosus,L/Wang—Xia,XIEWen,NING,SHEN.BloodCenterofWuhan,Wuhan430030,China[AbstractJObjective:Toevaluatethesignificanceofanti—Sm,anti—doubles~a
4、ndeddDNA(anti—dsDNA)andanti—ribosomalPproteinantibodies(antiI—rRNP)onthediagnosisinpatientswithsystemiclupuserythematosus(SLE).Methods:In93patientswithSLE,120patientsofotherautoimmunedisease(Non-SLE),anti—Sm,anti—dsDNAandanti-rRNPweretestedbyimmunofluoreseenee.Stat
5、isticalanalysisWasmadeusingSPSS13.0andthediferencesamonggroupswerecomparedusingZtest.Results:Theresultsshowedthatthepositiveratesofanti—Sm,anti—dsDNAandANTI—RRNPinSLEpatientsweremuchhigherthanthoseinpatientswithNon-SLEgroups(P<0.01)eitherindividualde—tectionorcombi
6、neddetection.OneorseveralantibodyCanbetestedinSLEpatientswitIlnegativeantibodyserum.CombineddetectionofthethreeautoantibodiesimprovedthespecificityandpoteivepredictivevalueofSLEdiagnosisexceptanti—dsDNA+anti—rRNP,butsensitivityandnegadvepredictivevaluewerelowerthan
7、individualdetection.Conclusion:Anti一n,anti.dsDNAandanti—rRNPhaveitselfsi鲥ficanceindi—agnosis.Thecombineddeterminationmayhaveimportantsignificanceindiagnosis,diferentialdiagnosisinpatientswithSLE.1KeywordsJAnti—Sm;Anti—doublestrandedDNA;An【i—ribosomalPprotein;Antibo
8、diessystematiclupuse~thematosns自身免疫性疾病是自身免疫功能异常紊乱的性率较低。近几年,有学者研究表明:anti.rRNP对一类疾病,通常在免疫细胞、自身抗体的参与下,导SLE的诊断有高度的特异性。本研究通过对系统性致组织器官损伤及功能障碍。系统性红斑狼疮是常
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