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时间:2020-05-20
《术前血清促甲状腺激素对甲状腺乳头状癌颈侧区淋巴结转移的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、夕卜科杂志2014年12月第22卷第12期JClinSurg,December2014,Vo1.22,No.12·899··论著·术前血清促甲状腺激素对甲状腺乳头状癌颈侧区淋巴结转移的影响董鸿李兴睿刘谨文逯超易继林[摘要】目的探讨术前血清促甲状腺激素(TSH)水平对甲状腺乳头状癌侧方淋巴结转移的影响。方法回顾性收集2011年1月至2014年5月问首诊收治以最终病理结果证实为甲状腺乳头状癌且行颈侧区淋巴结清扫的病例,阈值效应分析、多元Logistic回归分析等方法分析术前血清TSH对颈侧区淋巴结转移的影响。结果共收
2、集157例甲状腺乳头状癌病例,术前平均TSH为(2.48±1.91)~IU/ml,术前血清TSH与侧方淋巴结转移存在相关性,阈值效应分析显示两者相互关系存在分段特征,在<1.475~IU/ml时,随着TSH浓度的升高,颈侧区淋巴结转移风险升高,多因素Logistic回归显示该段TSH对颈侧区淋巴结转移具有独立作用。血清TSH浓度>1.475~IU/ml时,并无上述结果。结论术前血清TSH对甲状腺乳头状癌颈侧区淋巴结转移可能存在影响,不同浓度的血清TSH对颈侧区淋巴结转移的影响不同,相关的机制尚不明确,宜进一步讨论
3、。[关键词]甲状腺乳头状癌;促甲状腺激素;颈侧区淋巴结转移[中图分类号]R653[文献标识码]A[DOI]10.3969/j.issn.1005-6483.2014.12.008Effectofpreoperativeserumthyroidstimulatinghormoneonlaterallymphnodemetastasisinpa·pillarythyroidcarcinomaDONGHong,LI几g—rui,LIUJin—wen,eta1.(DepartmentofBreastandThroidSu
4、rgery,TongfiHospital。TongfiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China)[Abstract]ObjectiveToinvestigatetheefectofpreoperativeserumthyroidstimulatinghormone(TSH)onlateralcervicallymphnodemetastasis(LCNM)inpapillarythyroidcarcinoma
5、.MethodsFromJanuary2011toMay2014,aretrospectiveanalysiswasperformedinpatientsadmittedinWuhanTon~iHospital,whowerediagnosedaspapillarythyroidcarcinomabypathologicalresultandreceiveddissectionoflateralcervicallymphnode.Thresholdeffectandmultivariatelogisticregr
6、essionwereaccomplishedtoanalyzetheeffectsofpreoperativeserumTSHonLCNM.ResultsAtotalof157patientswerereviewed.ThemeanpreoperativeTSHwas(2.48±1.91)IxlU/m1.TherewascorrelationbetweenpreoperativeserumTSHandLCNMinthesepatients,andathresholdefectwasnoticed.Inpatien
7、tswithTSHlessthan1.475~IU/ml。theriskofLCNMincreasedwiththeelevationofserumTSHconcentration.MuhivariatelogisticregressionconfirmedtheindependenteffectofTSHonLCNM.ButinotherpatientswithTSHgreaterthanorequalto1.475ixlU/ml。therewerenosimilarresults.ConclusionPreo
8、perativeserumTSHmayaffectLCNMandtheinfluenceiSnotthesamewhentheTSHconcentrationiSdifferent.FurtherdiscussioniSre.quiredforclarifyingthespecificmechanisms.[Keywords]papillarythyroidcarcino
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