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时间:2020-05-20
《输血前不规则抗体筛查与临床输血安全.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、国际检验医学杂志2012年9月第33卷第17期IntJLabMed,September2012,Vo1.33,No.17·临床检验研究论著·输血前不规则抗体筛查与I临床输血安全李文静,蒋学兵,王燕菊,任爱玲,陈丽,刘慧珠(海军总医院输血科,北京100048)摘要:目的回顾性分析该院不规则抗体产生的频率及其特异性,探讨不规则抗体筛查阳性时的分析处理方法和临床意义,以确保l盏床输血安全。方法对2005年11月至2010年7月在该院拟输血或手术备血的10479例患者进行不规则抗体筛查,结果阳性的标本送北京市血液中心进行抗体鉴定,分析抗体特
2、异性。结果检出不规则抗体阳性7O例,阳性率为0.67,其中有临床意义的抗体49例,包括血液病22例、恶性肿瘤12例、良性肿瘤5例、肾病4例、其他疾病6例,血液病和肿瘤患者占79.6,抗体鉴定确定自身抗体1o例;自身抗体和同种抗体4例;确定同种特异性抗体35例。结论输血前不规则抗体筛查十分必要,发现不规则抗体筛查阳性一定要做进一步的抗体鉴定,并选择无相应抗原的配血相合的血液输注。关键词:不规则抗体;自身抗体;同种抗体;输血DOI:10.3969/j.issn.1673—4130.2012.17.008.文献标识码:A文章编号:1673
3、—4130(2012)17-2065—02IrregularantibodyscreeningbeforebloodtransfusionandclinicaltransfusionsafetyLiWenjing,JiangXuebing,WangYanju,RenAiling,ChenLi,LiuHuizhu(DepartmentofBloodTransfusion,NavyGeneralHospital,Beijing100048,China)Abstract:ObjectiveTodiscusstheclinicalvalue
4、andmethodsofanalysisandprocessingwhentheirregularantibodyscreeningwaspositivethrougharetrospectiveanalysisoffrequencyandspecificityinproducingirregularantibodies,inordertoensureclinicaltransfusionsafety.MethodsFromNovember2005toJuly2010,10479patientsforbloodtransfusion
5、orsurgeryinthehospitalscreenedirregularantibodies.ThespecimenswithpositiveresultsweresenttoBloodCenterofBeijingforantibodyidentificationandantibodyspecificityanalysis.Results70caseswithirregularantibodypositivewerefoundin10479patients.Positiveratewas0.67.Therewere49cas
6、eswithclinicallysignificantantibodiesamongthem,including22casesofhemopathy,12casesofmalig—nanttumor,5casesofbenigntumor,4casesofkidneydisease,and6casesofotherdiseases.Throughtheantibodyappraisal,itwasconfirmed10caseswithauto—antibodies,4caseswithauto—antibodiesandallo—
7、antibodies,and35caseswithspecificityallo—antibod—ies.ConclusionItisnecessarytoscreenirregularantibodiesbeforebloodtransfusion.Iftheresultofirregularantibodyscreeningispositive,itisbeobligedtoauthenticateantibodiesfurtherandchoosethebloodwithnocorrespondingantigensfortr
8、ansfusion,inordertoensurethesafety.Keywords:irregularantibody;auto—antibody;allo—antibody;bloodtransfusion红细胞血型不规则抗体可
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