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时间:2020-05-19
《脑梗死患者血清同型半胱氨酸水平与颈动脉粥样硬化的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、46现代检验医学杂志第3O卷第3期2015年5月JModLabMed,Vo1.30,No.3,May.2015脑梗死患者血清同型半胱氨酸水平与颈动脉粥样硬化的相关性研究王兴宁,李慧,米思蓉,屈宁,惠玉芬,冯莉,雷光星(延安大学附属医院检验科,陕西延安716000)摘要:目的研究脑梗死患者血清同型半胱氨酸(Hcy)水平与颈动脉粥样硬化的相关性。方法选择2013年1月~11月入住延安大学附属医院的脑梗死患者281例为脑梗死组,以同期140例体检正常者作为对照组,采用循环酶法测定血清Hcy水平,并进行颈动脉彩色多普勒超声检查,根据颈动脉超声检查结果将脑梗死组进一步分为动脉正常组、内膜增厚
2、组、软斑组、混合斑组及硬斑组,采用统计学软件包SPSS19.0进行分析。结果脑梗死组患者血清Hc:Y水平为19.78±5.21p.mol/L,明显高于对照组1O.24士3.33umol/L(P3、7,83.1和77.3,脑梗死各组与对照组相比差异均有统计学意义(P4、CarotidAtherOscler0sisinPatientswithCerebralInfarctionWANGXing—ning,LIHui,MISi—rong,QUNing,HUIYu-fen,FENGLi,LEIGuang—xing(DepartmentofClinicalLaboratory。A{filiatedHospitalofYananUniversity,ShaanxiYanan716000,China)Abstract:ObjectiveTostudytherelationshipbetweenhomocysteine(Hcy)andcarotidathero5、sc1er0sisinpatientswithcer—ebralinfarction.MethodsDuringJanuaryandNovember2013,281patientswithcerebralinfarctionfromAffiliatedHospitalofYan’anUniversitywereprovidedthebloodsamplesascerebralinfarctiongroup,140healthyvolunteersservedascontrolgroup.SerumHcywasdetectedbyenzymaticcycleassay.Accordi6、ngtotheresultsofcarotidarteryultrasonography,cerebralinfarctiongroupwasdividedintofivegroups:arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroup.ThestatisticallysignificancewasanalyzedbySPSS19.0.ResultsTheserumHcylevelofcer—ebralinfarctiongroupwas19.78±57、.21/lmol/L,significantlyhigherthanthecontrolgroup10.24±3.33/zmol/L(P<0.001).TheserumHcylevelsofcontrolgroup,arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroupwere10.244-3.33,15.204-2.99,17.034-1.
3、7,83.1和77.3,脑梗死各组与对照组相比差异均有统计学意义(P4、CarotidAtherOscler0sisinPatientswithCerebralInfarctionWANGXing—ning,LIHui,MISi—rong,QUNing,HUIYu-fen,FENGLi,LEIGuang—xing(DepartmentofClinicalLaboratory。A{filiatedHospitalofYananUniversity,ShaanxiYanan716000,China)Abstract:ObjectiveTostudytherelationshipbetweenhomocysteine(Hcy)andcarotidathero5、sc1er0sisinpatientswithcer—ebralinfarction.MethodsDuringJanuaryandNovember2013,281patientswithcerebralinfarctionfromAffiliatedHospitalofYan’anUniversitywereprovidedthebloodsamplesascerebralinfarctiongroup,140healthyvolunteersservedascontrolgroup.SerumHcywasdetectedbyenzymaticcycleassay.Accordi6、ngtotheresultsofcarotidarteryultrasonography,cerebralinfarctiongroupwasdividedintofivegroups:arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroup.ThestatisticallysignificancewasanalyzedbySPSS19.0.ResultsTheserumHcylevelofcer—ebralinfarctiongroupwas19.78±57、.21/lmol/L,significantlyhigherthanthecontrolgroup10.24±3.33/zmol/L(P<0.001).TheserumHcylevelsofcontrolgroup,arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroupwere10.244-3.33,15.204-2.99,17.034-1.
4、CarotidAtherOscler0sisinPatientswithCerebralInfarctionWANGXing—ning,LIHui,MISi—rong,QUNing,HUIYu-fen,FENGLi,LEIGuang—xing(DepartmentofClinicalLaboratory。A{filiatedHospitalofYananUniversity,ShaanxiYanan716000,China)Abstract:ObjectiveTostudytherelationshipbetweenhomocysteine(Hcy)andcarotidathero
5、sc1er0sisinpatientswithcer—ebralinfarction.MethodsDuringJanuaryandNovember2013,281patientswithcerebralinfarctionfromAffiliatedHospitalofYan’anUniversitywereprovidedthebloodsamplesascerebralinfarctiongroup,140healthyvolunteersservedascontrolgroup.SerumHcywasdetectedbyenzymaticcycleassay.Accordi
6、ngtotheresultsofcarotidarteryultrasonography,cerebralinfarctiongroupwasdividedintofivegroups:arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroup.ThestatisticallysignificancewasanalyzedbySPSS19.0.ResultsTheserumHcylevelofcer—ebralinfarctiongroupwas19.78±5
7、.21/lmol/L,significantlyhigherthanthecontrolgroup10.24±3.33/zmol/L(P<0.001).TheserumHcylevelsofcontrolgroup,arterynormalgroup,intimalthickeninggroup,softplaquegroup,mixedplaquegroupandhardplaquegroupwere10.244-3.33,15.204-2.99,17.034-1.
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