缺氧诱导因子-1a血清水平与冠状动脉钙化的相关性及临床诊断价值.pdf

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1、贵卅医药2015年3月第39卷第3期·207·缺氧诱导因子一1a血清水平与冠状动脉钙化的相关性及临床诊断价值曾庆娜黄山△许健冯勤颖张春阳陈洁田禾刘志琴。王荣品(1．贵阳医学院医学检验学院，贵州贵阳550004；2．贵州省人民医院临床检验中心，贵州贵阳550002；3．贵州省人民医院心内科，贵州贵阳550002；4．贵州省人民医院放射科，贵州贵阳550002)摘要目的探讨HIF-la血清水平与冠状动脉钙化的关系及临床诊断价值。．方法采用EIISA法检测经双源CT检查诊断为无钙化积分和有不同钙化积分的冠心病患者血清中HIF一1a水平，并进行统计分

2、析，绘制其ROC曲线分析其诊断性能。结果HIF一1a在对照组与不同钙化积分疾病组之间、以及对照组与疾病组之间其血清浓度水平差异显著，疾病组中HIF_1a含量明显高于对照组；钙化积分与HIF一1a呈正相关(P<0．05)；ROC曲线显示HIF一1a其曲线下面积为0．826，诊断阈值为56．53pg／mL，诊断敏感度为73．3O，特异性为73．50，Youden指数为0．517。结论HIF-1a在对照组和疾病组中表达不同，与钙化积分呈正相关，对冠心病诊断价值明显，对临床预防和早期诊断冠心病起到了作用。关键词缺氧诱导因子1a；冠心病；冠状动脉钙化；

3、诊断价值Clinicaldiagnosisvalueandtherelationshipbetweenhypoxiainduciblefactor-1aserumlevelsandcoronaryarterycalcificationZengQingna，HuangShan，XuJian。，FengQinying，ZhangChunyang，ChenJie，TianHe，LiuZhiqin。，WangRongpin．1．GuiyangMedicineLaboratoryCollege，GuizhouMedicalUniversity，Guiy

4、ang550004，China．2．TheClinicalLaboratoryCenterofGuizhouPeople’SHospita1，Guiyang550002，China．3．DepartmentofCardiologyGuizhouPeople’SHospital，Guiyang550002，China．4．DepartmentofRadiologyofGuizhouPeople’SHospita1，Guiyang550002，China．Abstract0bjectiveToinvestigatetheclinicaldiagn

5、osisvalueofserumHIF—lalevelandtherelationshipbetweencoronaryarterycalcification．MethodBythetestofdualsourceCTinspectiondiagnosisfornoncalcificationscoreandserumHIF一1alevelinpatientswithcoronaryheartdiseaseindifferentcalcificationscorebyELISAmeth—od，andstatisticalanalysis，to

6、analyzethediagnosticperformanceoftheR0Ccurvedrawing．ResultHIF1abetweencontrolgroupanddifferentcalcificationdiseasesgroup，andbetweenthecontrolgroupandthegroupofdiseaseswhoseserumconcentrationlevelsignificantly，thecontentofHIF一1aindiseasegroupweresignificantlyhigherthanthecon

7、trolgroup．CalcificationscorewaspositivelycorrelatedwithHIF—la(P

8、easegroup，Calcificationwaspositivelyassociatedwithanobviouscoronaryheartdiseasedia