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《肌酐比值的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第2O卷5期Journa天lof津Tia医nj科inM史ed学ica学lU报niversityVo1.2O.N0.52014年9月Sep.2014389文章编号1006—8147(2014)05—0389—03中年男性2型糖尿病患者促甲状腺激素与尿钙/肌酐比值的相关性研究李凤英’,朱铁虹(1.天津医科大学研究生院,天津300070;2.天津医科大学总医院内分泌科,天津300052)摘要目的:探讨中年男性2型糖尿病患者促甲状腺激素与尿钙/肌酐比值的相关性。方法:根据血促甲状腺激素(TsH)水平将516例中年
2、男性2型糖尿病患者分为低TSH组、正常TSH组和高TSH组,测量身高、体质量、血压、空腹血糖、血肌酐、碱性磷酸酶、血钙、血磷、TSH、24h尿钙、尿磷、尿肌酐。结果:随着TSH水平升高,中年男性2型糖尿病患者尿钙及尿钙/eL酐比值逐步降低(均P*<0.05)。多元线性回归分析经年龄、糖尿病病程等因素调整后仍显示TSH是影响尿钙/肌酐比值的相关因素(=一0.024,P<0.05)。结论:中年男性2型糖尿病患者TSH与尿钙/肌酐比值呈负相关,TSH是影响尿钙排泄率的独立影响因素。关键词促甲状腺激素;尿钙/肌酐
3、比值;糖尿病,2型中图分类号R587.1文献标志码ARelationshipbetweenthyroidstimulatinghormoneandurinarycalcium/creatinineexcretioninmiddle-agedmanwithtype2diabetesLIFeng-ying,ZHUTie-hong(1.GraduateSchool,TianjinMedicalUniversity,Tianjin300070,China;2.DepartmentofEndocrinology,G
4、eneralHospital,TianjinMedicalUniversity,Tianjin300052,China)AbstractObjective:ToinvestigatetherelationshipbetweenthyroidstimulatinghormonefiSH)andurinarycalcium/creatinineexcretioninmiddle-agedmanwithtype2diabetes.Methods:Fivehundredandsixteenmiddle-agedm
5、anwithtype2diabeteswereincludedinthestudy.BasedontheirTSH,thesestibjectsweredividedintothreegroups:lowTSHgroup,normalTSHgroupandhighTSHgroup.Height,weight,bloodpressure,fastingblood~.glucose,serumcreatinine,alkalinephosphatase,sernmcalcium,sernmphosphorus
6、,TSH,24hurinarycalcium,urinaryphosphorus,urinarycreatinineweremeasured.Results:Arelationshipoflowercalciumandlowerurinarycalcium/creatinineexcretionwithincreasingTSH,evenafteradjustingageanddiabeticduration,wasfound(both7、ysisshowedthatTSHcouldbeassociatedwithurinarycalcium/creatinineexcretion(/3=-0.024,P<0.05).Conclusion:TSHhasanegativecorrelationwithurinarycalcium/creatinineexcretioninmiddle—agedmanwithtype2diabetes,anditisanindependentactingfactorofurinarycalciumexcreti8、onrate.Keywordsthyroidstimulatinghormone;urinarycalcium/creatinineexcretion;diabetesmellitus,type2流行病学资料调查显示,2型糖尿病(DM)患性影响。因此本研究旨在探讨中年男性T2DM患者者较普通人群并发骨质疏松(osteoporosis,OP)的发TSH水平的变化情况及TSH与U—Ca/Cr的相关性。病率和OP性骨折的危险性明显增
7、ysisshowedthatTSHcouldbeassociatedwithurinarycalcium/creatinineexcretion(/3=-0.024,P<0.05).Conclusion:TSHhasanegativecorrelationwithurinarycalcium/creatinineexcretioninmiddle—agedmanwithtype2diabetes,anditisanindependentactingfactorofurinarycalciumexcreti
8、onrate.Keywordsthyroidstimulatinghormone;urinarycalcium/creatinineexcretion;diabetesmellitus,type2流行病学资料调查显示,2型糖尿病(DM)患性影响。因此本研究旨在探讨中年男性T2DM患者者较普通人群并发骨质疏松(osteoporosis,OP)的发TSH水平的变化情况及TSH与U—Ca/Cr的相关性。病率和OP性骨折的危险性明显增
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