黄体酮联合寿胎丸加减治疗复发性流产.pdf

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1、·720·WORLDCHINESEMEDICINEMay．2015，Vo1．10，No．5黄体酮联合寿胎丸加减治疗复发性流产傅娇郭慧梅(广东省中西医结合医院妇科，佛山，528200)摘要目的：观察黄体酮联合寿胎丸治疗封闭抗体阴性复发性流产疗效。方法：将2012年1月至2014年1月在我院门诊或住院治疗的200例封闭抗体阴性复发性流产患者随机分为对照组(n=100)和治疗组(n=100)。对照组为传统保胎治疗，肌注HCG、黄体酮，治疗组采用黄体酮合寿胎丸中药汤剂口服，治疗16周后进行疗效统计分析，对比2组妊娠成功率及封闭抗体转阳率。结果：治疗组妊娠成功76例，妊娠成功

2、率为76％，对照组妊娠成功52例，成功率为52％，两者比较有显著统计学意义(P<0．05)；封闭抗体转阳率方面，治疗组转阳69例，转阳率为69％，治疗组转阳58例，转阳率58％，2组比较有显著统计学意义(P<0．05)。结论：黄体酮联合寿胎丸治疗封闭抗体阴性复发性流产疗效确切，能明显提高妊娠成功率、封闭抗体转阳率，无不良反应，治疗成本低廉，值得临床推广及进一步研究。关键词封闭抗体阴性复发性流产；免疫治疗；黄体酮；滑胎；寿胎丸ProgesteroneCombinedwithShoutaiPiHintheTreatmentofRecurrentSpontaneousAb

3、ortionAssociatedwithBlockingAntibodyNegativeFuJiao，GuoHuimei(GynecologicalhospitalinGuangdongProvince，combiningtraditionalChineseandWesternMedicine，Foshaa528200，China)AbstractObjective：ToobservethecurativeeffectofprogesteronecombinedwithShoutaiPillinthetreatmentofrecurrentsport—taneous

4、abortionassociatedwithnegativeblockingantibody．Methods：Torandomlydivideoutpatientsandinpatientswhoseektreatmentforrecurentspontaneousabortionofnegativeblockingantibodytypeinourhospital(fromJanuaryof2012toJanuaryof2014)intocontrolgroup(n=100)andtreatmentgroup(n=100)．Traditionaltocolytic

5、therapyasintramuscularinjectionofHCGandprogesteronewasgiventothecontrolgroup．Bycontrast，progesteronecombinedwithShouTaiWandecoctionwasgiventothetreatmentgroup．After16weeksoftreatment，thesuccessrateandconversionrateofblockingantibodiesnegativeweretom—pared．Results：Pregnancysuccessratewa

6、s76％(76cases)inthetreatmentgroupand52％(52cases)inthecontrolgroup．Bothoftheresultswereofstatisticalsignificance(P<0．05)．Astotheblockingantibodypositiveconversionrate，thetreatmentgroupwas69％(69cases)andthecontrolgroupwas58％(58cases)，andbothwereofstatisticalsignificance(P<0．05)．Conclusion

7、：ProgesteronecombinedwithShoutaiPillinthetreatmentofblockingantibodynegativerecurrentabortionisofobviousefficacyandcansignificantlyimprovetheSuccessrateofpregnancyandtheconversionrateofantibodies．Noadversereactionhasmanifested．Withalowtreatmentcost，thetreatmentofprogesteronecombinedw