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《抗磷脂抗体综合征、血栓前状态与早发型重度子痫前期发病的相关研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、海南医学2013年8月第24卷第16期HainanMedJ,Aug.2013,Voi.24,No.16doi:10.3969/j.issn.1003—6350.2013.16.0992抗磷脂抗体综合征、血栓前状态与早发型重度子痫前期发病的相关研究肖海燕,席雅娟(深圳市宝安区龙华人民医院妇产科,检验科,广东深圳518109)【摘要】目的探讨抗磷脂抗体综合征、血栓前状态与早发型重度子痫前期发病之前的相关性,寻找早期诊断早发型重度子痫前期的指标。方法收集我院住院分娩的早发型(早发组)及晚发型重度子痫前期患者(晚发组洛
2、70例。同时随机选取70例同期入院的正常孕妇为对照组。对比各组患者外周血甘油三脂(TG)、胆固醇(TC)、出凝血功能指标以及血清抗心磷脂抗体、坑B:一GPI抗体等表达水平。结果三组问出凝血功能对比中,早发组抗凝血酶(A:r)}舌性显著低于晚发组及正常对照组,差异均有统计学意义<0.05)。三组TC、TG及D-Z.聚体对比中,早发组D一二聚体平均秩次为76.6mg/L,显著高于晚发组的58.3mg/L和正常组的54.1mgm,差异均具有统计学意义3、高于晚发组及正常组,差异有统计学意义(P<0.05)。结论抗凝血酶、D--聚体、抗ACA抗体阳性率及抗一GPI抗体可作为早期诊断早发型重度子痫前期的指标。【关键词】早发型重度子痫;抗凝血酶;D一二聚体【中图分类号】R714.245【文献标识码】A【文章编号】1003---6350(2013)l6-_240_o3Correlationstudyonantiphospholipidantibodysyndrome,prethromboticstateandtheincidenceofearlyonsetsevere4、preeclampsia.XIAOHai-yan,XIYa--juan2.DepartmentofObs~trwsandGynecology~,DepartmentofClinicalLaboratorya,LonghuaPeopleItospitalofBao"anDistrictofShenzhen,Shenzhen51810~Guangdong,CHINA【Abstract】ObjeetiveTostudythecorrelationofantiphospholipidantibodysyndrome,p5、rethromboticstatewiththeincidenceofearlyonsetseverepreeclampsia,andtoinvestigatetheindexesfortheearlydiagnosisofearlyon.setseverepreeclampsia.MethodsPuerperantsinourhospitalwithearlyonsetseverepreeclampsia(theearlygroup,n=70)andlateonsetseverepreeclampsia(th6、elategroup,n=70)werecollected.Atthesametime,70normalpregnantwomenwererandomlyselectedasthecontrolgroup.Thethreegroupswerecomparedinglycerolthreefat(TG),cho-lesterol(TC),coagulationindexandserumanticardiolipinantibody,anti-/32一GPIantibodylevels.ResultsForcoag7、u—lationindex,theantithrombin(AT)activityintheearlygroupwassignificantlylowerthanthatinthelategroupandthecontrolgroup(尸8、oupfP<0.05).ThepositiveratesofACAanti—bodyandanti-~2一GPIantibodyintheearlygroupwassignificantlyhigherthanthoseinthelategroupandthecontrolgroup(P
3、高于晚发组及正常组,差异有统计学意义(P<0.05)。结论抗凝血酶、D--聚体、抗ACA抗体阳性率及抗一GPI抗体可作为早期诊断早发型重度子痫前期的指标。【关键词】早发型重度子痫;抗凝血酶;D一二聚体【中图分类号】R714.245【文献标识码】A【文章编号】1003---6350(2013)l6-_240_o3Correlationstudyonantiphospholipidantibodysyndrome,prethromboticstateandtheincidenceofearlyonsetsevere
4、preeclampsia.XIAOHai-yan,XIYa--juan2.DepartmentofObs~trwsandGynecology~,DepartmentofClinicalLaboratorya,LonghuaPeopleItospitalofBao"anDistrictofShenzhen,Shenzhen51810~Guangdong,CHINA【Abstract】ObjeetiveTostudythecorrelationofantiphospholipidantibodysyndrome,p
5、rethromboticstatewiththeincidenceofearlyonsetseverepreeclampsia,andtoinvestigatetheindexesfortheearlydiagnosisofearlyon.setseverepreeclampsia.MethodsPuerperantsinourhospitalwithearlyonsetseverepreeclampsia(theearlygroup,n=70)andlateonsetseverepreeclampsia(th
6、elategroup,n=70)werecollected.Atthesametime,70normalpregnantwomenwererandomlyselectedasthecontrolgroup.Thethreegroupswerecomparedinglycerolthreefat(TG),cho-lesterol(TC),coagulationindexandserumanticardiolipinantibody,anti-/32一GPIantibodylevels.ResultsForcoag
7、u—lationindex,theantithrombin(AT)activityintheearlygroupwassignificantlylowerthanthatinthelategroupandthecontrolgroup(尸8、oupfP<0.05).ThepositiveratesofACAanti—bodyandanti-~2一GPIantibodyintheearlygroupwassignificantlyhigherthanthoseinthelategroupandthecontrolgroup(P
8、oupfP<0.05).ThepositiveratesofACAanti—bodyandanti-~2一GPIantibodyintheearlygroupwassignificantlyhigherthanthoseinthelategroupandthecontrolgroup(P
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