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《复方丹参注射液辅助治疗重症急性胰腺炎的临床疗效研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·520·WORLDCHINESEMEDICINEApr.2015,Vo1.10,No.4复方丹参注射液辅助治疗重症急性胰腺炎的临床疗效研究臧泽林祝瑞黄文炼(四川省南充市中心医院重症医学科,四川,637000)摘要目的:观察复方丹参注射液辅助治疗重症急性胰腺炎(SevereAcutePancreatitis,SAP)的临床疗效。方法:将本院收治的50例SAP住院患者为研究对象,并根据入院先后顺序随机分为对照组和治疗组,2组患者均接受内科常规治疗,如禁食、胃肠减压、扩容、纠正电解质紊乱、抗感染、抑制胰腺分泌、营养
2、支持等,治疗组在上述常规治疗基础上加用复方丹参注射液20mL联合0.9%Nacl溶液250mL静脉滴注,每日1次。2组均以10d为1个疗程,1个疗程结束后观察2组患者治疗前后症状、体征以及实验室指标的变化。结果:1)治疗组首次排便的时间、肠呜音恢复时间、腹部压痛消失时间均短于对照组,且差异有统计学意义(P<0.05);2)2组并发症发生率、外科手术中转率及病死率比较均具统计学意义(P<0.05);3)治疗组治疗组血浆内毒素、血清淀粉酶、白细胞计数恢复正常的时间均短于对照组(P<0.05),经过治疗后治疗组血清肿
3、瘤坏死因子.ct(TumorNecrosisFactoralpha,TNF一)、白细胞介素一8(Interleukin一8,IL一8)、白细胞介素-6(Interleu—kin-6,IL-6)水平明显低于对照组(P<0.05)。结论:复方丹参注射液辅助治疗SAP可促进胃肠功能恢复,降低并发症发生率及病死率,临床可进一步推广。关键词SAP;肠道黏膜屏障功能;炎性因子;复方丹参注射液ClinicalEficacyofCompoundSalviaMiltiorrhizaInjectionintheAajuvantTh
4、erapyofSevereAcutePancreatitisZangZelin,ZhuRui,HuangWenlian(NanchongCentralHospital,CriticalCare,Nanchong637000,China)AbstractObjective:Toobservetheclinicalcurativeeffectofthecompoundsalviamiltiorrhizainjectioninadjuvanttherapyofsevereacutepancreatitis(SAP).
5、Methods:FiftypatientswithSAPwerereceivedandtreatedinourhospita1.Theywererandomlydividedintothecontrolgroupandthetreatmentgroup.Bothgroupsreceivedconventionaltreatment,i.e.fasting,gastrointestinalde—compression,expansionofbloodvolume,correctionofelectrolytedi
6、sturbances,anti—infectiontherapy,inhibitionofpancreaticsecre—tion,nutritionalsupport,etc.Ontopofconventionaltreatment,thetreatmentgroupreceivedintravenousdripof20mlcompoundsal—viamihiorrhizainjectioncombinedwith250ml0.9%NaC1solution,onceperday.Bothgroupsrece
7、ived10daysoftreatment,andwereobservedofthechangesinsymptoms,signsandlaboratoryindexesbeforeandaftertreatment.Results:1)Firstdefecationtime,bowelsoundrecoverytime,andabdominaltendernessdisappeartimeofthetreatmentgroupwereshorterthanthatofthecon-trolgroup,andt
8、hedifferenceswerestatisticallysignificant(P<0.05);2)Complicationsrate,surgicaloperationrateandcasefa—talityrateofthetwogroupswerewithstatisticaldifferences(P<0.05);3)Inthetreatmentgroup,thetimeo
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