非烯胺途径有机催化醛醇缩合反应立体选择性合成邻卤代醇和Knoevenagel产物.pdf

《非烯胺途径有机催化醛醇缩合反应立体选择性合成邻卤代醇和Knoevenagel产物.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、ChineseJournalofCatalysis36(2015)1093—1100催化学报2015年第36卷第7期lvcw-vv．chxb．CrlavaiIabIeatwwSi—eeedirectComScienceDirectjournaIhomepage：www+．爱lls蕻爨}tam／loeate／chnjcELSEVIERArticleStereoselectivesynthesisofvic-halohydrinsandanunusualKnoevenagelproductfromanorg

2、anocatalyzedaldolreaction：Anon．ena●minemode_●●●≯■P．B．Thorat,S．V．Goswami，V．P．Sondankar，S．R．BhusareDepartmentofChemistry,DnyanopasakCollege,Parbhani-431401，MS,IndiaARTICLEINF0ABSTRACTArticlehistory：Stereoselectivesynthesisbyanaldolreactionbetweenchloroacet

3、oneandaldehydewasstudiedReceived5January2015usingasynthesizedchiralorganocatalystandtriethylamine．Thereactiongavec【一chloro—B—hydroxyAccepted10February2015ketonesinexcellentyieldwithhighantiselectivityandenantioselectivity．ThechiralorganocatalystPublished

4、20July2015wasalsousedintheKnoevenagelreaction，whichgavecc-cyano-B-hydroxyketonesatalowtem-peratureandtheusualKnoevenagelproductatahightemperature．BothproductswereobtainedinKoavords：goodtomoderateeldwithgoodantiselectivityinthecaseofoc-cyano—p-hydroxyketo

5、nederiva-fives．Aldolreaction@2015DalianInstituteofChemicalPhysics，ChineseAcademyofSciences．AsymmetricsynthesisPublishedbyElsevierB．V．A1lrightsreserved．Chl0rOacetOneDiastere0selectivit、，HydroxypropanoateKnoevenagelreactionPyrrolidinederivative1．In仃oductio

6、nactivemethylenecompoundinthepresenceofabaseisknownasKnoevenagelcondensation【8]．TheKnoevenagelreactionisVic．halohydrinsareimportantintermediatesforthesynthe—animportantC—Cbondformingreactionbecausethesynthe—sisofbiologicallyactivecompoundsandnaturalprodu

7、ctssuchsizedalkenesareveryusefulintermediatesinorganicsynthesisasbagonists【1】Jsubstitutedpyrrolidines[2】，polychlorosul—『91．Forexample，Knoevenagelc0ndensationhasbeensuccess—folipid[3】，andinsectsexpheromones[4】．Thesemoleculesarefullycombinedwithhetero-Diel

8、s-A1derreactions．Michaelad．buildingblocksforvariousbioactiveproductsandnaturalditionreactions，enereactions，andsigmatropicrearrangementcompounds．Thusefortshavebeenmadetodevelopeffectivef0rthesynthesisofhighlyfunctionalizedm